Apathy is more severe in vascular than amnestic mild cognitive impairment in a community: The Kurihara Project
Apathy is more severe in vascular than amnestic mild cognitive impairment in a community: The Kurihara Project
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DOI：
10.1111/pcn.12098
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发表时间：
2013-11-01
影响因子：
11.9
通讯作者：
Meguro, Kenichi
中科院分区：
文献类型：
--
作者：
Nakamura, Kei;Kasai, Mari;Meguro, Kenichi
目的：本研究的目的是估计冷漠的患病率，并比较血管性轻度认知功能障碍（vMCI），遗忘型MCI（amMCI），和其他类型的使用临床评估自发性（CAS）。方法：同意参加这项研究的590名社区居民，年龄75岁，居住在日本栗原。在590名受试者中，221名的临床痴呆评分（CDR）为0（正常）; 295名的CDR为0.5（轻度认知障碍; MCI）; 74名的CDR为1+（痴呆）。将CDR 0.5的受试者分为三组：55名vMCI受试者（Erkinjuntti埃塔尔，amMCI组91例，其他类型149例。为了评估冷漠的各个方面，我们使用了三个CAS分量表：临床访谈（CAS 1），自我评估（CAS 2）和照顾者评估（CAS 3）。然后进行三项分析，以确定：（i）CAS的有效性;（ii）冷漠的患病率在CDR 0与CDR 0.5与CDR 1+;和（iii）冷漠的患病率在正常vMCI与amMCI与其他type.Results：CAS与冷漠评价量表进行了验证。3组间CAS 1、CAS 2、CAS 3差异有统计学意义（P
Aim:The aim of this study was to estimate the prevalence of apathy, and to compare vascular mild cognitive impairment (vMCI), amnestic MCI (amMCI), and other type using Clinical Assessment for Spontaneity (CAS).Methods:Agreement to take part in the study was obtained from 590 community dwellers, aged 75years living in Kurihara, Japan. Of the 590 subjects, 221 had a clinical dementia rating (CDR) of 0 (normal); 295 had CDR 0.5 (mild cognitive impairment; MCI); and 74 had CDR 1+ (dementia). The CDR 0.5 subjects were divided into three groups: 55 with vMCI (Erkinjuntti etal. criteria), 91 with amMCI and 149 with other type. To evaluate the various aspects of apathy, we used the three CAS subscales: clinical interview (CAS1), self-evaluation (CAS2), and caregiver assessment (CAS3). Three analyses were then performed to determine: (i) the validity of CAS; (ii) the prevalence rate of apathy in CDR 0 versus CDR 0.5 versus CDR 1+; and (iii) the prevalence rate of apathy in normal versus vMCI versus amMCI versus other type.Results:CAS was validated with the Apathy Evaluation Scale. There were significant differences among the three CDR groups in CAS1, CAS2 and CAS3 (P