Are circadian rhythms new pathways to understand Autism Spectrum Disorder?
Are circadian rhythms new pathways to understand Autism Spectrum Disorder?
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DOI：
10.1016/j.jphysparis.2017.06.002
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发表时间：
2016-11-01
期刊：
影响因子：
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通讯作者：
Georgieff, N
中科院分区：
文献类型：
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作者：
Geoffray, M-M;Nicolas, A;Georgieff, N
自闭症谱系障碍（ASD）是一种常见的神经发育障碍。ASD可能是基因和环境之间复杂相互作用的结果，逐渐改变了大脑结构和功能的发育。昼夜节律是一个复杂的内在计时系统，由几乎和身体细胞一样多的时钟组成。它们调节各种生理和行为过程，如睡眠-觉醒节律。ASD通常与睡眠障碍和褪黑激素水平低有关。这第一点提出的假设，昼夜节律可能有一个含义，在ASD病因。此外，昼夜节律是由转录因子CLOCK和BMAL 1驱动的自动调节遗传反馈环产生的，这些转录因子在不同的细胞环境中驱动大量时钟控制基因（CCG）的每日转录模式。其中，一些CCG编码与ASD易感性相关的突触分子。此外，有证据表明昼夜节律控制大脑发育过程的时间。
Autism Spectrum Disorder (ASD) is a frequent neurodevelopmental disorder. ASD is probably the result of intricate interactions between genes and environment altering progressively the development of brain structures and functions. Circadian rhythms are a complex intrinsic timing system composed of almost as many clocks as there are body cells. They regulate a variety of physiological and behavioral processes such as the sleep-wake rhythm. ASD is often associated with sleep disorders and low levels of melatonin. This first point raises the hypothesis that circadian rhythms could have an implication in ASD etiology. Moreover, circadian rhythms are generated by auto-regulatory genetic feedback loops, driven by transcription factors CLOCK and BMAL1, who drive transcription daily patterns of a wide number of clock-controlled genes (CCGs) in different cellular contexts across tissues. Among these, are some CCGs coding for synapses molecules associated to ASD susceptibility. Furthermore, evidence emerges about circadian rhythms control of time brain development processes.