Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli.
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli.
复制标题
肠上皮屏障功能障碍的机理，粘附的大肠杆菌。
DOI：
10.1016/j.jcmgh.2016.10.004
复制
发表时间：
2017-01
影响因子：
7.2
通讯作者：
McCole DF
中科院分区：
文献类型：
--
作者：
Shawki A;McCole DF
病原体的扩张，如粘附侵袭性大肠杆菌（AIEC）的扩张，是一种与炎症性肠病相关的新兴因素。肠上皮屏障是抵御这些病原体的第一道防线。炎症在改变上皮屏障中起关键作用，并且是参与促进AIEC的扩展和发病的主要因素。反过来，AIEC可以通过靶向屏障的多个元素来加剧肠上皮屏障功能障碍。上皮屏障的一个关键要素是紧密连接。越来越多的证据表明，AIEC可能选择性地靶向紧密连接的蛋白质组分，导致屏障通透性增加。这可能代表了AIEC可能有助于炎症性肠病发展的一种机制。这篇综述文章讨论了AIEC破坏上皮紧密连接功能和肠屏障功能的潜在机制。
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens. Inflammation plays a critical role in altering the epithelial barrier and is a major factor involved in promoting the expansion and pathogenesis of AIEC. AIEC in turn can exacerbate intestinal epithelial barrier dysfunction by targeting multiple elements of the barrier. One critical element of the epithelial barrier is the tight junction. Increasing evidence suggests that AIEC may selectively target protein components of tight junctions, leading to increased barrier permeability. This may represent one mechanism by which AIEC could contribute to the development of inflammatory bowel disease. This review article discusses potential mechanisms by which AIEC can disrupt epithelial tight junction function and intestinal barrier function.