Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.
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DOI：
10.1038/nn.3850
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发表时间：
2014-12
影响因子：
25
通讯作者：
Small SA
中科院分区：
文献类型：
--
作者：
Brickman AM;Khan UA;Provenzano FA;Yeung LK;Suzuki W;Schroeter H;Wall M;Sloan RP;Small SA
齿状回（DG）是海马结构中的一个区域，其功能随着人类衰老而下降，因此被认为是与年龄相关的记忆衰退的可能来源。然而，需要因果关系的证据表明，DG相关的记忆力下降，否则健康的老年人可以改善的干预措施，提高DG功能。我们首先使用功能性磁共振成像（fMRI）的高分辨率变体来映射与年龄相关的DG功能障碍的精确部位，并开发其功能定位于该解剖部位的认知任务，从而解决了这个问题。然后，在一项对照随机试验中，我们应用这些工具研究了健康的50-69岁受试者，他们食用了高或低可可含量的饮食3个月。通过功能磁共振成像和认知测试，发现高黄烷醇干预可增强DG功能。我们的研究结果表明，DG功能障碍是年龄相关的认知功能下降的驱动程序，并建议非药物手段改善。
The dentate gyrus (DG) is a region in the hippocampal formation whose function declines in association with human aging and is therefore considered to be a possible source of age-related memory decline. Causal evidence is needed, however, to show that DG-associated memory decline in otherwise healthy elders can be improved by interventions that enhance DG function. We addressed this issue by first using a high-resolution variant of functional magnetic resonance imaging (fMRI) to map the precise site of age-related DG dysfunction and to develop a cognitive task whose function localized to this anatomical site. Then, in a controlled randomized trial, we applied these tools to study healthy 50–69-year-old subjects who consumed either a high or low cocoa–containing diet for 3 months. A high-flavanol intervention was found to enhance DG function, as measured by fMRI and by cognitive testing. Our findings establish that DG dysfunction is a driver of age-related cognitive decline and suggest non-pharmacological means for its amelioration.