Hemostatic risk factors and insulin sensitivity, regional body fat distribution, and the metabolic syndrome
Hemostatic risk factors and insulin sensitivity, regional body fat distribution, and the metabolic syndrome
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DOI：
10.1210/jc.2004-1292
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发表时间：
2005-01-01
影响因子：
5.8
通讯作者：
Stevenson, JC
中科院分区：
文献类型：
--
作者：
Godsland, IF;Crook, D;Stevenson, JC
血栓和纤溶系统的紊乱是胰岛素抵抗、肥胖和代谢综合征的特征。然而，很少有研究中，这些关系已经探讨了主要是无症状的个人使用复杂的措施，胰岛素敏感性和局部肥胖。在106名男性（年龄32 - 68岁，体重指数20 - 34 kg/m2）中测量止血系统的变量。胰岛素敏感性采用最小模型分析，局部肥胖采用双能x线吸收法。聚类的相互关联的变量进行了评估的因素分析的统计技术。血浆促凝血因子VII和X、抗凝蛋白C和S以及纤溶酶原激活物抑制剂-1水平与中心体脂肪总量和百分比呈正相关（r = 0.25 ~ 0.38; P < 0.05），与胰岛素敏感性呈负相关（蛋白S除外; r =-0.24 ~-0.35; P < 0.05）。在因子分析中，促凝血因子VII和X，蛋白质C和S，纤溶酶原激活物抑制剂-1的变量，解释了最大比例的数据（39.2%）的集群组件。该聚类中包括的其他变量是代谢综合征的典型变量和血清γ-谷氨酰转移酶活性。这些结果表明，因子VII和X以及蛋白质C和S是代谢综合征相互关联的紊乱的特征。与肥胖和肝酶活性的关联表明肝脏脂肪沉积的参与。
Disturbances in the thrombotic and fibrinolytic systems are a feature of insulin resistance, obesity, and the metabolic syndrome. However, there are few studies in which these relationships have been explored in mainly asymptomatic individuals using sophisticated measures of insulin sensitivity and regional adiposity. Variables of the hemostatic system were measured in 106 men ( aged 32 - 68 yr; body mass index, 20 - 34 kg/m(2)). Insulin sensitivity was measured by minimal model analysis and regional adiposity by dual energy x-ray absorptiometry. Clustering of intercorrelated variables was assessed by the statistical technique of factor analysis. Plasma levels of procoagulant factors VII and X, anticoagulant proteins C and S, and plasminogen activator inhibitor- 1 correlated positively with total and percent central body fat ( r = 0.25 - 0.38; P < 0.05) and negatively with insulin sensitivity ( except protein S; r = - 0.24 to - 0.35; P < 0.05). On factor analysis, procoagulant factors VII and X, proteins C and S, and plasminogen activator inhibitor-1 were components of the cluster of variables that explained the greatest proportion of the variance in the data (39.2%). Other variables included in this cluster were those typical of the metabolic syndrome and also serum gamma-glutamyl transferase activity. These results suggest that factors VII and X and proteins C and S are features of the intercorrelated disturbances of the metabolic syndrome. Associations with adiposity and liver enzyme activity suggest the involvement of hepatic fat deposition.