Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis.
Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis.
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DOI：
10.5732/cjc.011.10319
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发表时间：
2012-04
影响因子：
--
通讯作者：
Lin HK
中科院分区：
文献类型：
--
作者：
Wang G;Chan CH;Gao Y;Lin HK
S期激酶相关蛋白2（Skp 2）属于F-box蛋白家族。它是SCF E3泛素连接酶复合物的组分。Skp 2已被证明通过靶向几种细胞周期调节蛋白进行泛素化和降解来调节细胞增殖，包括细胞周期蛋白依赖性激酶抑制剂p27。Skp 2还被证明显示致癌功能，因为在许多人类癌症中观察到其过表达。本文综述了Skp 2在调节细胞衰老、癌症进展和转移中的新作用，以及靶向Skp 2治疗人类癌症的潜力。
S-phase kinase-associated protein 2 (Skp2) belongs to the F-box protein family. It is a component of the SCF E3 ubiquitin ligase complex. Skp2 has been shown to regulate cellular proliferation by targeting several cell cycle-regulated proteins for ubiquitination and degradation, including cyclin-dependent kinase inhibitor p27. Skp2 has also been demonstrated to display an oncogenic function since its overexpression has been observed in many human cancers. This review discusses the recent discoveries on the novel roles of Skp2 in regulating cellular senescence, cancer progression, and metastasis, as well as the therapeutic potential of targeting Skp2 for human cancer treatment.
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