Do Pharmacokinetics Explain Persistent Restenosis Inhibition by a Single Dose of Paclitaxel?
Do Pharmacokinetics Explain Persistent Restenosis Inhibition by a Single Dose of Paclitaxel?
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DOI：
10.1161/circinterventions.111.967794
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发表时间：
2012-06-01
影响因子：
5.6
通讯作者：
Scheller, Bruno
中科院分区：
文献类型：
--
作者：
Speck, Ulrich;Cremers, Bodo;Scheller, Bruno
背景：本研究的目的是研究单次短期给药后动脉壁紫杉醇的清除情况。方法与结果：在幼猪或成年哥廷根小型猪的非动脉粥样硬化冠状动脉中，对未安装或未安装支架的略微超大的紫杉醇包被球囊（剂量3或9 μ g/mm(2)）进行充气。使用高效液相色谱/紫外检测或质谱法测量血浆、动脉段和残余心脏（未处理动脉）的紫杉醇含量长达180天。血管造影评估管腔狭窄。血浆中紫杉醇浓度保持不变
Background-The purpose of this study was to investigate the elimination of paclitaxel from the arterial wall after a single short administration with a coated balloon.Methods and Results-Slightly oversized paclitaxel-coated balloons (dose 3 or 9 mu g/mm(2)) without or with premounted stents were inflated in nonatherosclerotic coronary arteries of either young domestic pigs or adult Goettingen minipigs. The paclitaxel content of plasma, arterial segments, and residual hearts (without treated arteries) was measured for up to 180 days using high-performance liquid chromatography/ultraviolet detection or mass spectrometry. Angiograms were evaluated for lumen narrowing. The paclitaxel concentration in plasma remained