Age- and gender-specific BMI in terms of the lowest mortality in Japanese general population
Age- and gender-specific BMI in terms of the lowest mortality in Japanese general population
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DOI：
10.1038/oby.2008.342
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发表时间：
2008-10-01
期刊：
影响因子：
6.9
通讯作者：
Muto, Takashi
中科院分区：
文献类型：
--
作者：
Matsuo, Tomoaki;Sairenchi, Toshimi;Muto, Takashi
目的：本研究的主要目的是根据日本人口的最低死亡率（风险最低点BMI）建立年龄和性别特定的BMI，然后将其与(i)由类似研究确定的白人BMI和（ii）官方BMI指南进行比较。方法和程序：1993年，日本茨城县共有32 060名年龄在40-79岁之间的男性和61 916名女性接受了健康检查，并随访至2003年。为了确定年龄和性别特异性的风险最低点BMI，通过Cox比例风险模型计算BMI转换后的二次模型的系数和最低点。这包括1/BMI的二次项和调整值（年龄、酒精摄入量和吸烟状况）。结果：对于年龄和性别类别，全因死亡率风险与BMI类别之间的关系均以u形曲线表示。40-59岁和60-79岁年龄组男性的风险最低点bmi分别为23.4和25.3 kg/m(2)。同样，在女性中，风险最低点bmi分别为21.6和23.4 kg/m(2)。讨论：在日本普通人群中，60-79岁年龄组的风险最低点BMI高于40-59岁年龄组，这与白人的研究相似，年龄依赖性风险最低点BMI与官方指导标准不同。我们的发现强调了根据年龄控制体重的重要性。
Objective: The primary purposes of our study were to establish age- and gender-specific BMIs in terms of lowest mortality (risk nadir BMIs) for the Japanese population, and to then compare those to (i) BMIs for whites as determined by similar studies and to (ii) the official BMI guidelines.Methods and Procedures: A total of 32,060 men and 61,916 women aged 40-79 years underwent health check-ups in Ibaraki prefecture, Japan, in 1993 and were followed through 2003. To determine the age- and gender-specific risk nadir BMIs, coefficients and the lowest point from a quadratic model with transformed BMI were calculated by a Cox proportional hazard model. This included the quadratic term of 1/BMI and adjusted values (age, alcohol intake, and smoking status).Results: For both age and both gender categories, the relationship between all-cause mortality risk and BMI categories are illustrated as U-shaped curves. The risk nadir BMIs for men in the age groups of 40-59 and 60-79 years were 23.4 and 25.3 kg/m(2), respectively. Similarly, in women, the risk nadir BMIs were 21.6 and 23.4 kg/m(2), respectively.Discussion: Among the general Japanese population, the risk nadir BMI for the age group of 60-79 years was higher compared to the age group of 40-59 years, which was similar to the study for whites, and the age- dependent risk nadir BMI differed from the official guidelines criteria. Our findings underscore the importance of weight control following appropriate indicators of body weight according to age.