The Design and Synthesis of Planar Chiral Ligands and Their Application to Asymmetric Catalysis
The Design and Synthesis of Planar Chiral Ligands and Their Application to Asymmetric Catalysis
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平面手性配体的设计合成及其在不对称催化中的应用
DOI：
10.1055/s-0033-1340487
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发表时间：
2014-03-17
期刊：
影响因子：
2
通讯作者：
Zhang, Wanbin
中科院分区：
文献类型：
--
作者：
Butt, Nicholas A.;Liu, Delong;Zhang, Wanbin
基于二茂铁和二茂二茂铁的平面手性配体已被开发并用于过渡金属催化的不对称烯丙基取代、不对称氢化和不对称共轭加成反应。最常见的二茂铁配体，其在环戊二烯环上具有双（恶唑啉）取代基，已经被修饰以产生新的平面手性C（2）对称配体，其中一些在上述反应中显示出优异的潜力。一系列平面手性茂配体也被开发出来，它们的活性不同于它们的二茂铁对应物。1引言2平面手性配体的设计与合成2. 1二茂铁基配体2. 2钌茂基配体3平面手性配体在不对称反应中的应用3. 1不对称烯丙基烷基化反应3. 2不对称烯丙基胺化反应3. 3烯胺作为亲核试剂的不对称烯丙基烷基化反应3. 4芳醛的不对称烷基化反应3. 5不对称氢化反应3. 61，4-不对称共轭反应4总结
Ferrocene- and ruthenocene-based planar chiral ligands have been developed and used in transition-metal-catalyzed asymmetric allylic substitutions, asymmetric hydrogenations, and asymmetric conjugate addition reactions. The most common ferrocene ligands, which have bis(oxazoline) substituents on the cyclopentadiene rings, have been modified to create new planar chiral C (2)-symmetric ligands, some of which have shown excellent potential in the aforementioned reactions. A series of planar chiral ruthenocene ligands have also been developed and their activities differ from those of their ferrocene counterparts. 1Introduction 2The Design and Synthesis of Planar Chiral Ligands 2.1Ferrocene-Based Ligands 2.2Ruthenocene-Based Ligands 3Applications of Planar Chiral Ligands in Asymmetric Reactions 3.1Asymmetric Allylic Alkylation 3.2Asymmetric Allylic Amination 3.3Asymmetric Allylic Alkylation with Enamines as Nucleophiles 3.4Asymmetric Alkylation of Aryl Aldehydes 3.5Asymmetric Hydrogenation 3.61,4-Asymmetric Conjugation Reactions 4Summary