Prepulse inhibition deficits in patients with panic disorder
Prepulse inhibition deficits in patients with panic disorder
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DOI：
10.1002/da.10026
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发表时间：
2002-01-01
影响因子：
7.4
通讯作者：
Vollenweider, FX
中科院分区：
文献类型：
--
作者：
Ludewig, S;Ludewig, K;Vollenweider, FX
前脉冲抑制（PPI）是感觉运动门控的一种操作措施，在几种神经精神疾病中减少，这些疾病的特征是对侵入性或不相关刺激的抑制或门控缺陷。在临床上，惊恐障碍（PD）患者被描述为在抑制对感觉和认知事件的反应方面存在困难。因为这些困难可能是由于信息处理早期阶段的失败，我们检查了PD患者的PPI。在惊恐障碍患者（m/f = 10，10）和年龄和性别匹配的健康对照组（m/f = 11，10）中评估了声惊吓反应性、习惯化和PPI（30，60，120，240和2,000 ms刺激间隔）。采用DSM-IV标准的结构化临床访谈评估PD患者，以苯二氮卓类药物治疗作为排除标准。惊恐障碍患者在30、60和240 ms前脉冲条件下表现出正常的星形反应性、降低的习惯性和显著降低的PPI。在PD组中，高特质和状态焦虑的患者比低特质和状态焦虑的患者表现出更少的PPI。此外，在PD患者中，PPI降低与高特质焦虑显著相关，但与状态焦虑无关。这些数据表明，早期阶段的感觉信息处理是异常的PD患者。这些观察到的PPI缺陷可能反映了惊恐障碍中抑制或门控信息的更普遍的困难。高特质焦虑和PPI不足之间的相关性支持了这一假设，即感觉运动门控异常是PD受试者的持久特征。(C)2002 Wiley-Liss，Inc.
Prepulse inhibition (PPI) is an operational measure of sensorimotor gating that is reduced in several neuropsychiatric disorders that are characterized by deficits in inhibition or gating of intrusive or irrelevant stimuli. Clinically, panic disorder (PD) patients have been described as having difficulties in inbibition of responding to sensory and cognitive events. Because such difficulties may be due to failures in early stages of information processing, we examined PPI in patients with PD. Acoustic startle reactivity, habituation, and PPI (30-, 60-, 120-, 240-, and 2,000-ms interstimulus intervals) were assessed in patients with panic disorder (m/f = 10, 10) and age- and gender-matched healthy controls (m/f = 11, 10). PD patients were assessed with structured clinical interview for DSM-IV criteria with benzodiazepine treatment as an exclusion criterion. Panic disorder patients exhibited normal star-tie reactivity, reduced habituation, and significantly reduced PPI in the 30-, 60-, and 240ms prepulse conditions. Within the PD group, the patients with high trait and state anxiety exhibited less PPI than patients with low trait and state anxiety. Furthermore, in PD patients, decreased PPI correlated significantly with high trait but not state anxiety. These data indicate that early stages of sensory information processing are abnormal in patients with PD. These observed deficits in PPI could reflect a more generalized difficulty in suppressing or gating information in panic disorder. The correlation between high trait anxiety and deficient PPI supports the hypothesis that sensorimotor gating abnormalities are an enduring feature of subjects with PD. (C) 2002 Wiley-Liss, Inc.