A new folding paradigm for repeat proteins
A new folding paradigm for repeat proteins
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DOI：
10.1021/ja0524494
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发表时间：
2005-07-27
影响因子：
15
通讯作者：
Regan, L
中科院分区：
文献类型：
--
作者：
Kajander, T;Cortajarena, AL;Regan, L
经典的一维Ising模型定量描述了一系列设计的共有三肽重复蛋白的折叠/去折叠转变，从而代表了一种新的重复蛋白折叠模式.此外，对于任何蛋白质，第一次，理论模型预测折叠/展开过渡中点和过渡宽度。
The folding/unfolding transitions of a series of designed consensus tetratricopeptide repeat proteins are quantitatively described by the classical one-dimensional Ising model, which thus represents a new folding paradigm for repeat proteins. Moreover, for the first time for any protein, a theoretical model predicts the folding/unfolding transition midpoint and the width of the transition.