Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions
Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions
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DOI：
10.1016/j.tet.2018.04.019
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发表时间：
2018-06-21
期刊：
影响因子：
2.1
通讯作者：
Rueping, M.
中科院分区：
文献类型：
--
作者：
Poscharny, K.;Fabry, D. C.;Rueping, M.
介绍了以二苯甲酮和呋喃为原料合成氧杂环己烷的方法。间歇和流动体系中的紫外光照射使[2+2]环加成反应得以进行，并可通过手动和自动方式合成多种氧杂环烷。通过一种新的自优化光反应系统实现了对高产率反应参数的识别。(C)2018爱思唯尔有限公司。保留所有权利。
A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system. (C) 2018 Elsevier Ltd. All rights reserved.