Effects of local geometry and fluid dynamics on regional platelet deposition on artificial surfaces.
Effects of local geometry and fluid dynamics on regional platelet deposition on artificial surfaces.
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DOI：
10.1161/01.atv.13.12.1806
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发表时间：
1993-12
期刊：
影响因子：
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通讯作者：
R. Schoephoerster;Finn Oynes;German Nunez;Monsoor Kapadvanjwala;Mrinal K. Dewanjee
中科院分区：
文献类型：
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作者：
R. Schoephoerster;Finn Oynes;German Nunez;Monsoor Kapadvanjwala;Mrinal K. Dewanjee
血液与材料相互作用的一个重要方面是人造表面上血小板的激活、粘附和随后的聚集，所有这些都直接受到局部流体动力学的影响。这项工作的目的是将各种血管几何形状（包括狭窄、动脉瘤和单独的收缩和扩张几何形状）产生的局部流体动力学条件的变化与局部血小板沉积的体外定量测量直接关联起来。我们使用 111In 标记的血小板，通过这些几何形状的轴对称模型，直接测量血小板沉积作为沿着四个 Lexan 流动室的轴向位置的函数。血小板沉积在观察到的血流再循环和重新附着区域中最大，而在高剪切和分离位置中最小。对于狭窄的几何形状，血小板沉积增加的两个不同区域是明显的，一个靠近狭窄喉部，一个远离狭窄喉部。动脉瘤区域血小板密度近似线性增加，沿血流方向增加。通过比较血小板沉积与局部流体流线方向，我们发现，由于血小板和血细胞沿着局部弯曲的流线（速度分量垂直于血管壁）向血管壁的对流运输增强，血小板沉积在某些区域增加。
An important aspect of blood-material interactions is the activation, adhesion, and subsequent aggregation of blood platelets on the artificial surface, all of which are directly affected by local fluid dynamics. The objective of this work was to directly correlate changing local fluid dynamic conditions produced by various vessel geometries, including stenosis, aneurysm, and separate contraction and expansion geometries, with quantitative in vitro measurements of regional platelet deposition. We directly measured platelet deposition as a function of axial position along four Lexan flow chambers with axisymmetric models of these geometries using 111In-labeled platelets. Platelet deposition was maximum in observed areas of flow recirculation and reattachment and minimum in locations of high shear and separation. For the stenosis geometry, two distinct regions of increased platelet deposition were apparent, one proximal to and one distal to the stenosis throat. An approximately linear increase in platelet densities was produced in the aneurysm region, increasing in the direction of flow. Through a comparison of platelet deposition with local fluid streamline orientation, we have shown that platelet deposition is increased in certain areas due to the enhanced convective transport of platelets and blood cells to the vessel wall along locally curved streamlines with velocity components perpendicular to the vessel wall.