Analysis of 256 Cases of Classic Fever of Unknown Origin
Analysis of 256 Cases of Classic Fever of Unknown Origin
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DOI：
10.2169/internalmedicine.53.2218
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Naito, Toshio
中科院分区：
文献类型：
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作者：
Yamanouchi, Masashi;Uehara, Yuki;Naito, Toshio
目的不明原因发热(FUO)的病因因地区和时间不同而不同。方法对1994年8月至2012年12月收治的256例符合经典型FUO诊断标准的患者的病历资料进行分析。结果患者平均年龄55岁(18~94岁)。感染占27.7%(71例)，非感染性炎症性疾病占18.4%(47例)，恶性肿瘤占10.2%(26例)，其他占14.8%(38例)，不明原因占28.9%(74例)。最常见的单一原因是人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征(AIDS)(n=17)。NIID和恶性肿瘤在65岁患者中比在患者中更常见
Objective The causes of fever of unknown origin (FUO) vary depending on the region and time period. We herein present a study of patients with classic FUO where we investigated differences based on patient background factors, such as age and causative diseases, and changes that have occurred over time.Methods We extracted and analyzed data from the medical records of 256 patients >= 18 years old who met the criteria for classic FUO and were hospitalized between August, 1994 and December, 2012.Results The median age of the patients was 55 years (range: 18-94 years). The cause of FUO was infection in 27.7% of the patients (n=71), non-infectious inflammatory disease (NIID) in 18.4% (47), malignancy in 10.2% (26), other in 14.8% (38), and unknown in 28.9% (74). The most common single cause was human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (n=17). NIID and malignancy were more common in patients >= 65 years old than in patients