Hyper-acute EEG alterations predict functional and morphological outcomes in thrombolysis-treated ischemic stroke: a wireless EEG study.
Hyper-acute EEG alterations predict functional and morphological outcomes in thrombolysis-treated ischemic stroke: a wireless EEG study.
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DOI：
10.1007/s11517-020-02280-z
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发表时间：
2021-01
影响因子：
3.2
通讯作者：
Manganotti P
中科院分区：
文献类型：
--
作者：
Ajčević M;Furlanis G;Naccarato M;Miladinović A;Buoite Stella A;Caruso P;Cillotto T;Accardo A;Manganotti P
由于受试者间的差异很大，卒中后早期预后具有挑战性，仍需要能够提供进一步预后信息的客观生物标记物。溶栓前超急性期定量脑电参数与预后的关系仍有待研究。因此，在接受溶栓治疗的中风患者中，研究了早期脑电生物标记物与短期/长期功能和形态结果之间的可能相关性。对20例超急性(<； ，发病4.5h)前壁缺血性卒中患者在再通治疗前进行脑电图检查。研究预后参数(7天/12个月美国国立卫生研究院卒中评分NIHSS、12个月改良Rankin评分MRS、最终脑梗塞体积)与治疗前脑电参数的相关性。相对增量功率、α功率、增量/α(DAR)、(Delta+theta)/(α+β)比值与NIHSS7天(Rho = 分别为0.80，− 0.81，0.76，0.75)和12个月时NIHSS(分别为0.73，− 0.78，0.74，0.73)以及最终梗塞体积(分别为0.75，− 0.70，0.78，0.62)显著相关。12个月时MRS- ≤ -2的良好结果与DAR参数相关(p = 0.008)。在治疗前的早期阶段，通过无线脑电等非侵入性和便携技术获得的神经生理生物标志物可能有助于作为客观参数进行短期/长期结果预测，从而更好地制定治疗策略。研究方案框图和主要发现。入院时评估包括在紧急情况下进行无线脑电采集(<； 4.5起卒中)，在再通溶栓治疗前提取脑电特征。我们研究样本中的主要发现总结在两个不同的例证中风患者中，他们在溶栓前脑电参数的不同变化导致不同的最终脑梗塞体积扩大和短期/长期临床结果(NIHSS，MRS)。图形摘要
Owing to the large inter-subject variability, early post-stroke prognosis is challenging, and objective biomarkers that can provide further prognostic information are still needed. The relation between quantitative EEG parameters in pre-thrombolysis hyper-acute phase and outcomes has still to be investigated. Hence, possible correlations between early EEG biomarkers, measured on bedside wireless EEG, and short-term/long-term functional and morphological outcomes were investigated in thrombolysis-treated strokes. EEG with a wireless device was performed in 20 patients with hyper-acute (< 4.5 h from onset) anterior ischemic stroke before reperfusion treatment. The correlations between outcome parameters (i.e., 7-day/12-month National Institutes of Health Stroke Scale NIHSS, 12-month modified Rankin Scale mRS, final infarct volume) and the pre-treatment EEG parameters were studied. Relative delta power and alpha power, delta/alpha (DAR), and (delta+theta)/(alpha+beta) (DTABR) ratios significantly correlated with NIHSS 7-day (rho = 0.80, − 0.81, 0.76, 0.75, respectively) and NIHSS 12-month (0.73, − 0.78, 0.74, 0.73, respectively), as well as with final infarct volume (0.75, − 0.70, 0.78, 0.62, respectively). A good outcome in terms of mRS ≤ 2 at 12 months was associated with DAR parameter (p = 0.008). The neurophysiological biomarkers obtained by non-invasive and portable technique as wireless EEG in the early pre-treatment phase may contribute as objective parameters to the short/long-term outcome prediction pivotal to better establish the treatment strategies. Block diagram of study protocol and main findings. Assessment at admission including wireless EEG acquisition in emergency setting (< 4.5 from stroke onset), extracted EEG features before reperfusion thrombolytic treatment. The main findings in our study sample are summarized in two different exemplificative stroke patients with different pre-thrombolysis alterations of EEG parameters resulting in different final infarct volume extensions and short/long-term clinical outcomes (NIHSS, mRS). Graphical abstract
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影响因子：
3.3
作者：
Caruso, Paola;Naccarato, Marcello;Manganotti, Paolo
通讯作者：
Manganotti, Paolo
影响因子：
6.7
作者：
Reid, John M.;Gubitz, Gord J.;Phillips, Stephen J.
通讯作者：
Phillips, Stephen J.
影响因子：
14.5
作者：
Rossini, PM;Altamura, C;Tecchio, F
通讯作者：
Tecchio, F
影响因子：
158.5
作者：
Hacke, Werner;Kaste, Markku;Toni, Danilo
通讯作者：
Toni, Danilo
影响因子：
9.9
作者：
Adams, HP;Davis, PH;Hansen, MD
通讯作者：
Hansen, MD