Naked Sendai virus vector lacking all of the envelope‐related genes: reduced cytopathogenicity and immunogenicity

Naked Sendai virus vector lacking all of the envelope‐related genes: reduced cytopathogenicity and immunogenicity
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DOI：
10.1002/jgm.938
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发表时间：
2006-09
期刊：
The Journal of Gene Medicine
影响因子：
--
通讯作者：
M. Yoshizaki;T. Hironaka;H. Iwasaki;H. Ban;Y. Tokusumi;A. Iida;Y. Nagai;M. Hasegawa;M. Inoue
M. Yoshizaki;T. Hironaka;H. Iwasaki;H. Ban;Y. Tokusumi;A. Iida;Y. Nagai;M. Hasegawa;M. Inoue
中科院分区：
其他
文献类型：
--
作者：
M. Yoshizaki;T. Hironaka;H. Iwasaki;H. Ban;Y. Tokusumi;A. Iida;Y. Nagai;M. Hasegawa;M. Inoue

文献摘要

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仙台病毒（SeV）是一类新型的细胞质RNA载体，其无遗传毒性，在大多数哺乳动物细胞中感染和繁殖，并指导高水平的转基因表达。我们通过从SeV基因组中删除所有包膜相关基因来改进载体，从而降低其免疫原性。
Sendai virus (SeV) is a new class of cytoplasmic RNA vector that is free from genotoxicity that infects and multiplies in most mammalian cells, and directs high‐level transgene expression. We improved the vector by deleting all of the envelope‐related genes from the SeV genome and thus reducing its immunogenicity.