Small airway dysfunction and bronchial asthma control : the state of the art.
Small airway dysfunction and bronchial asthma control : the state of the art.
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DOI：
10.1186/s40733-015-0013-3
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发表时间：
2015-01-01
影响因子：
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通讯作者：
Micheletto, Claudio
中科院分区：
文献类型：
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作者：
Cottini, Marcello;Lombardi, Carlo;Micheletto, Claudio
根据国家和国际准则，实现和维持哮喘控制是疾病管理的主要目标。在严格对照的临床试验中，在目前可用的药物治疗下，大多数患者可以实现良好的哮喘控制，但基于大量人群的研究表明，在现实生活中，有相当一部分患者的哮喘控制水平未达到最佳水平，并报告生活方式受限，对生活质量造成了相当大的负担。治疗依从性和持久性差、不能正确使用吸入器、哮喘表型异质性和相关合并症是导致疾病控制不良的主要因素。现在，人们普遍认为，周围气道功能障碍已经存在于轻度哮喘患者中，是控制不良的关键因素。本文的目的是探讨小气道功能障碍与哮喘症状/控制之间的关系。因此，我们使用关键词进行PubMed搜索：小气道；哮喘（适用范围：人类，英语）和选定的哮喘患者研究人群的论文，报告了小气道参数的测量和临床症状/控制。
According to national and international guidelines, achieving and maintaining asthma control is a major goal of disease management. In closely controlled clinical trials, good asthma control can be achieved , with the medical treatments currently available, in the majority of patients , but large population-based studies suggest that a significant proportion of patients in real-life setting experience suboptimal levels of asthma control and report lifestyle limitations with a considerable burden on quality of life. Poor treatment adherence and persistence, failure to use inhalers correctly, heterogeneity of asthma phenotypes and associated co-morbidities are the main contributing factors to poor disease control. Now, it is widely accepted that peripheral airway dysfunction , already present in patients with mild asthma, is a key contributor of worse control. The aim of this paper is to investigate the association between small-airways dysfunction and asthma symptoms/control. We therefore performed a PubMed search using keywords : small airways; asthma (limits applied: Humans, English language) and selected papers with a study population of asthmatic patients, reporting measurement of small-airways parameters and clinical symptoms/control.