Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity

Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity
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DOI:
10.1562/2004-11-23-ra-378r1.1
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发表时间:
2005-07-01
影响因子:
3.3
通讯作者:
Petrich, JW
Petrich, JW
中科院分区:
生物学3区
文献类型:
--
作者:
Krishnamoorthy, G;Webb, SP;Petrich, JW

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Hydroxy and methoxy perylene quinones are synthesized in an attempt to isolate the essential spectroscopic and biological features of light-induced antiviral agents such as hypericin and hypocrellin. Unlike their naturally occurring counterparts, these synthetic quinones bear the carbonyl, hydroxyl, and methoxy groups in the "bay region." The hydroxy and methoxy compounds have rich absorption spectra with broad features in the visible (similar to 450-800 nm) and relatively more intense and narrow features at wavelengths