Multiple inducible thermogenic mechanisms in the development of cold acclimatization
Multiple inducible thermogenic mechanisms in the development of cold acclimatization
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DOI：
10.2478/fzm-2023-0011
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发表时间：
2023-05
期刊：
影响因子：
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通讯作者：
Huanyu Lu;Wen-jing Luo
中科院分区：
文献类型：
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作者：
Huanyu Lu;Wen-jing Luo
摘要极寒环境可增加心肌梗死、脑卒中、冻伤、低体温等危险，威胁人类健康和生命。产生的热量不足以维持核心体温是冻伤的主要原因。为了科普冷应激，人类和其他哺乳动物已经发展了冷习服能力来适应这种恶劣的环境。适应性非颤抖产热是冷习服的一种普遍形式。本文系统总结了三种诱导产热形式，包括食物摄入，昼夜节律和冷暴露在介导冷暴露下的非颤抖性产热中的作用，并提出了潜在的干预措施，以尽量减少寒冷温度对健康的不良影响。
Abstract Extreme cold environment can threaten human health and life through increasing the risk of myocardial infarction, stroke, frostbite, and hypothermia. Insufficient heat production to maintain core body temperature is a major cause of cold injury. To cope with cold stress, human and other mammals have developed the capacity of cold acclimatization to adapt to such a harsh environment. Adaptive non-shivering thermogenesis is a ubiquitous form of cold acclimatization. This review article systematically summarizes the role of three inducible thermogenic forms, including food intake, circadian rhythms, and cold exposure in mediating non-shivering thermogenesis under cold exposure and presents the potential interventions for minimizing the adverse health consequences of cold temperature.