APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians
APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians
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DOI：
10.1002/ana.20694
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发表时间：
2006-01-01
影响因子：
11.2
通讯作者：
Murrell, JR
中科院分区：
文献类型：
--
作者：
Gureje, O;Ogunniyi, A;Murrell, JR
自1992年以来，来自印第安纳州大学和伊巴丹大学的研究小组一直在收集和比较来自两个不同老年人群的数据，以确定痴呆症和阿尔茨海默病的危险因素。载脂蛋白E（APOE）基因型在2,245尼日利亚样本。其中，830人有诊断：459人正常，140人患有痴呆症，其中123人被诊断患有阿尔茨海默病。与其他人群相比，APOE β 4等位基因与阿尔茨海默病或痴呆症无显著相关性。约鲁巴人缺乏关联可能反映了遗传变异、环境因素以及遗传/环境相互作用。
Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE epsilon 4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions.