High-Quality T2-Weighted 4-Dimensional Magnetic Resonance Imaging for Radiation Therapy Applications
High-Quality T2-Weighted 4-Dimensional Magnetic Resonance Imaging for Radiation Therapy Applications
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DOI：
10.1016/j.ijrobp.2015.01.035
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发表时间：
2015-06-01
影响因子：
7
通讯作者：
Hu, Yanle
中科院分区：
文献类型：
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作者：
Du, Dongsu;Caruthers, Shelton D.;Hu, Yanle
目的：本研究的目的是提高前瞻性呼吸幅度触发的 4 维磁共振成像 (4DMRI) 方法的触发效率，并开发一种 4DMRI 成像协议，该协议可以提供 T2 加权，以实现更好的肿瘤可视化、良好的空间覆盖和空间分辨率，以及在合理的时间内进行呼吸运动采样，用于放射治疗应用。 方法和材料：使用呼吸信号在模拟研究中对呼吸状态分裂 (RSS) 和多次采集 (MSA) 方法进行分析比较和验证来自 10 名健康人类受试者。 RSS方法对于提高触发效率更为有效。它在前瞻性呼吸幅度触发的 4DMRI 中实施。 4DMRI 图像数据集是从 5 名健康人类受试者身上获取的。使用获取的 4DMRI 图像数据集估计肝脏运动。结果：模拟研究表明 RSS 方法比 MSA 方法更有效地提高触发效率。 RSS 和 MSA 方法的 4DMRI 采集时间平均减少了 36% 和 10%。人体研究表明，根据个人的呼吸模式，可以在 9 至 18 分钟内获得具有 10 个呼吸状态、60 个切片、空间分辨率为 1.5 x 1.5 x 3.0 mm 3 的 T2 加权 4DMRI。基于获取的 4DMRI 图像数据集，5 名受试者的肝脏位移峰峰值范围在上下、前后和左右方向上分别为 9.0 至 12.9 mm、2.5 至 3.9 mm 和 0.5 至 2.3 mm。结论：我们证明，通过 RSS 方法，在短时间内获得高质量 T2 加权 4DMRI 是可行的。放射治疗应用的合理时间。 (C) 2015 Elsevier Inc. 保留所有权利。
Purpose: The purpose of this study was to improve triggering efficiency of the prospective respiratory amplitude-triggered 4-dimensional magnetic resonance imaging (4DMRI) method and to develop a 4DMRI imaging protocol that could offer T2 weighting for better tumor visualization, good spatial coverage and spatial resolution, and respiratory motion sampling within a reasonable amount of time for radiation therapy applications.Methods and Materials: The respiratory state splitting (RSS) and multi-shot acquisition (MSA) methods were analytically compared and validated in a simulation study by using the respiratory signals from 10 healthy human subjects. The RSS method was more effective in improving triggering efficiency. It was implemented in prospective respiratory amplitude-triggered 4DMRI. 4DMRI image datasets were acquired from 5 healthy human subjects. Liver motion was estimated using the acquired 4DMRI image datasets.Results: The simulation study showed the RSS method was more effective for improving triggering efficiency than the MSA method. The average reductions in 4DMRI acquisition times were 36% and 10% for the RSS and MSA methods, respectively. The human subject study showed that T2-weighted 4DMRI with 10 respiratory states, 60 slices at a spatial resolution of 1.5 x 1.5 x 3.0 mm 3 could be acquired in 9 to 18 minutes, depending on the individual's breath pattern. Based on the acquired 4DMRI image datasets, the ranges of peak-to-peak liver displacements among 5 human subjects were 9.0 to 12.9 mm, 2.5 to 3.9 mm, and 0.5 to 2.3 mm in superior-inferior, anterior-posterior, and left-right directions, respectively.Conclusions: We demonstrated that with the RSS method, it was feasible to acquire high-quality T2-weighted 4DMRI within a reasonable amount of time for radiation therapy applications. (C) 2015 Elsevier Inc. All rights reserved.