Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese
Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese
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DOI：
10.1016/j.ajo.2006.09.029
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发表时间：
2007-02-01
影响因子：
4.2
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
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作者：
Ueta, Mayumi;Sotozono, Chie;Kinoshita, Shigeru
目得：研究日本人中HLA-I类抗原与Stevens-Johnson综合征（SJS）/中毒性表皮坏死松解症（TEN）伴眼部并发症的相关性。设计：病例对照研究。我们检测了组织相容性抗原基因HLA-A，-B，和-C的40日本SJS/10例眼部并发症患者和113例健康日本志愿者，通过聚合酶链反应扩增和随后的与序列特异性寡核苷酸探针（PCR-SSO）。结果：我们阐明了HLA-A*0206与日本人的SJS/TEN眼部并发症密切相关。结论：由于这一发现与其他地方报道的台湾汉族患者和白人患者的数据完全不同，这表明在HLA-SJS关联中存在强烈的种族差异，并指出需要在其他种族人群中进行研究以获得全球性的图像。
PURPOSE: To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complica- tions in Japanese.DESIGN: Case-control study.METHODS: We examined the histocompatibility antigen genes HLA-A, -B, and -C of 40 Japanese SJS/TEN patients with ocular complications and 113 healthy Japanese volunteers by polymerase chain reaction amplification and subsequent hybridization with sequence-specific oligonucleotide probes (PCR-SSO).RESULTS: We clarified that HLA-A*0206 is strongly associated with SJS/TEN with ocular complications in the Japanese.CONCLUSIONS: Because this finding is completely different from data reported elsewhere on Taiwanese Han Chinese patients and Caucasian patients, it suggests strong ethnic differences in the HLA-SJS association and points to the need for studies in other ethnic populations in order to obtain a global picture.