Aging-associated changes in cardiac gene expression.
Aging-associated changes in cardiac gene expression.
复制标题
衰老相关的心脏基因表达变化。
DOI：
10.1016/j.cardiores.2004.11.016
复制
发表时间：
2005
影响因子：
10.8
通讯作者：
Boheler,KennethR
中科院分区：
文献类型：
--
作者：
Volkova,Maria;Garg,Rahul;Dick,Salihah;Boheler,KennethR
心血管疾病（例如，血管疾病、中风、心力衰竭）在老年人中达到流行比例，并且是人类生存的主要限制。心脏结构和功能的心脏病相关变化代表心力衰竭（HF）综合征的主要危险因素，并且与基因表达模式的改变相关，所述基因表达模式的改变通常可以被视为基因转录物丰度的相对变化。理解这些变化背后的分子机制应该等同于定义衰老的遗传基础;然而，分析像衰老这样复杂的过程需要对生物多样性进行核算。直到最近，大多数转录本丰度的变化被确定在一个时间，但基因表达阵列的出现允许快速，大规模的表达谱。这提供了关于总基因表达的动态的信息，其可用于鉴定途径和阐明在衰老期间或响应于疾病可能受到影响的调节事件。重要的是，非常大的样本量或较小样本量研究的荟萃分析应足以解释基因表达改变的多样性，这些基因表达改变指导特定分子途径的改变，这些分子途径是衰老和疾病中心脏结构和功能变化的基础。
Cardiovascular diseases (e.g., vascular diseases, strokes, heart failure) reach epidemic proportions in the elderly and are the primary limits to survival in man. Age-associated changes in heart structure and function represent the major risk factors in heart failure (HF) syndromes and are associated with altered patterns of gene expression that can generally be seen as relative changes in the abundance of gene transcripts. An understanding of the molecular mechanisms underlying these changes should be tantamount to defining a genetic basis for aging; however, the analysis of processes as complicated as aging requires an accounting of biological diversity. Until recently, most of the changes in transcript abundance were identified one at a time, but the advent of gene expression arrays has permitted rapid, large-scale expression profiling. This has provided information about the dynamics of total gene expression, which can be used to identify pathways and elucidate regulatory events that may be affected during senescence or in response to disease. Importantly, very large sample sizes or meta-analyses of studies of smaller sample sizes should be sufficient to account for the diversity of altered gene expression that directs alterations in specific molecular pathways, which underlie changes in cardiac structure and function in senescence and disease.