GENERAL-PRINCIPLES OF ANTIBIOTIC TISSUE PENETRATION
GENERAL-PRINCIPLES OF ANTIBIOTIC TISSUE PENETRATION
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DOI：
10.1093/jac/15.suppl_a.59
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发表时间：
1985-01-01
影响因子：
5.2
通讯作者：
CUCHURAL, G
中科院分区：
文献类型：
--
作者：
BARZA, M;CUCHURAL, G
在平衡状态下，多孔毛细管两侧的游离药物浓度是相等的。然而，当血清和血管外部位的药物水平波动时，在达到这种平衡的过程中起作用的动态因素尚未得到很好的研究。本文综述了有关毛细管孔扩散和毛细管膜渗透的一些物理原理。强调表面积与体积比在确定达到平衡的各个阶段所需时间方面的重要性，并考虑了感染的影响。在平衡状态下，游离药物在血清和非特化血管外腔室中的AUC必须相等。因此，尽管给药方式（如连续输注与间歇给药）会影响血管外腔位的浓度-时间曲线，但不会影响这些部位的药物总体AUC。我们推导出了一个公式来估计细菌破坏药物时脓肿内的药物水平。简要考虑了在具有无孔毛细血管和主动运输系统的特殊地点的运输。在整个分析过程中，我们重点关注这些原理在体外模型中的应用，以及体外模型的潜在应用来证实这些原理。
It is well established that, at equilibrium, the concentrations of free drug on either side of a porous capillary are equal. However, the dynamic factors which operate on the way to achieving this equilibrium, while drug levels fluctuate in serum and extravascular sites, have been less well studied. This paper reviews some of the physical principles relating to diffusion through capillary pores and permeation through capillary membranes. Emphasis has been placed on the importance of the surface area-to-volume ratio in determining the time required to reach various stages of equilibrium The effects of infection have been considered. At equilibrium, the AUC of free drug in serum and non-specialized extravascular compartments must be equal Therefore, although the mode of administration (e.g. continuous infusion versus intermittent bolus) will affect the profile of the concentration-time curve in extravascular loci, it will not affect the overall AUC of drug in these sites. We have derived an equation to estimate the levels of drug within an abscess when bacteria are destroying the drug. Brief consideration has been given to transport in specialized sites with non-porous capillaries and with active transport systems. Throughout the analysis, we have focused on the application of these principles to in-vitro models and the potential use ofin-vitromodels to substantiate these principles.