Nosocomial transmission of hepatitis C virus in haemodialysis patients
Nosocomial transmission of hepatitis C virus in haemodialysis patients
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血液透析患者丙型肝炎病毒的院内传播
DOI：
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发表时间：
1996
影响因子：
12.7
通讯作者：
P. de Micco
中科院分区：
文献类型：
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作者：
X. D. de Lamballerie;M. Olmer;Dammar Bouchouareb;C. Zandotti;P. de Micco
对在同一单位接受治疗的114例血液透析患者进行的系统病毒学随访显示，37例（包括17例PCR阳性患者）为丙型肝炎病毒（HCV）血清阳性。在10例患者中检测到1b型HCV，并且在这一人群中比在法国东南部的肝胃肠道科治疗的整个患者人群中更常见。测定了7株1b型HCV E1/E2基因组序列。在4例患者中，在E1可变区和E2高变区（HVR 1）中检测到相似的菌株。此外，这4例患者中有2例在研究开始时为血清阴性和PCR阴性，在此期间未接受输血或移植。绘制系统发育树，证实这些菌株非常相似，并表明HCV通过该血液透析单元的医院途径传播。© 1996 Wiley利斯公司
A systematic virological follow‐up of 114 haemodialysis patients treated in the same unit showed that 37, including 17 PCR positive patients, were seropositive for hepatitis C virus (HCV). Type 1b HCV was detected in 10 patients and was much more frequent in this population than in the whole population of patients treated in the hepatogastroenterology departments in southeastern France. The E1/E2 genomic region of seven type 1b HCV strains was sequenced. In four patients, a similar strain was detected in both the E1 variable region and the E2 hypervariable region (HVR1). In addition, two of these four patients were seronegative and PCR negative at the beginning of the study and had not been transfused or transplanted during this period. A phylogenetic tree was drawn which confirmed that these strains were very similar and showed that HCV was transmitted via the nosocomial pathway in this haemodialysis unit. © 1996 Wiley‐Liss, Inc.