Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease.
Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease.
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Interleukin-22 可能是治疗 2 型糖尿病和冠状动脉疾病的双刃剑
DOI：
10.1155/2016/8254797
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发表时间：
2016
影响因子：
4.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Gong F;Wu J;Zhou P;Zhang M;Liu J;Liu Y;Lu X;Liu Z
2型糖尿病(T2 DM)和冠心病(CAD)均以慢性低度炎症为特征。Th17及其相关细胞因子在T2 DM和CAD中的作用尚不清楚。在这里，我们研究了5种与Th17相关的细胞因子(IL-17、IL-22、MIP-3α、IL-9和IL-27)在T2 DM、冠心病和T2 DM-CAD共病患者中的水平。IL-22在三种情况下均升高。血清IL-22升高与T2 DM和CAD的发生独立相关。相反，IL-22对葡萄糖和溶血磷脂酰胆碱(LPC)诱导的内皮细胞损伤有保护作用，高糖和LPC处理后内皮细胞上IL-22R1的表达增加。用IL-22R1抗体阻断IL-22R1可减弱IL-22的保护作用。提示IL-22在T2 DM和CAD中起双刃剑作用，可用于T2 DM和CAD等慢性炎症性疾病的治疗。
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC. Blocking of IL-22R1 with IL-22R1 antibody diminished the protective role of IL-22. Our results suggest that IL-22 functions as a double-edged sword in T2DM and CAD and that IL-22 may be used in the treatment of chronic inflammatory diseases such as T2DM and CAD.
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DOI：
10.4049/jimmunol.1302246
发表时间：
2015-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Peters A;Fowler KD;Chalmin F;Merkler D;Kuchroo VK;Pot C
通讯作者：
Pot C
影响因子：
4.4
作者：
Pastore, S;Mascia, F;Girolomoni, G
通讯作者：
Girolomoni, G
影响因子：
5.2
作者：
Frostegård J
通讯作者：
Frostegård J
影响因子：
39.3
作者：
Paneni F;Beckman JA;Creager MA;Cosentino F
通讯作者：
Cosentino F
影响因子：
7.7
作者：
Dalmas, Elise;Venteclef, Nicolas;Guerre-Millo, Michele
通讯作者：
Guerre-Millo, Michele