HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication.
HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication.
复制标题
HIV-1 特异性细胞毒性 T 淋巴细胞和 HIV-1 复制的控制。
DOI：
10.1007/bf00813502
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Walker,BD
中科院分区：
文献类型：
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作者：
Jassoy,C;Walker,BD
自从在感染者中发现了HIV-L特异性细胞毒性T淋巴细胞以来的10年里，这种细胞免疫反应的研究比任何其他人类病毒感染都要深入。尽管在了解宿主防御的这一臂的许多特征方面取得了实质性进展，但关于CTL在防止疾病进展中的作用的基本问题仍未确定，CTL未能在感染过程中有效地与病毒竞争也无法解释。来自众多实验室的最新进展现在开始阐明这些问题，并形成新假设的产生基础。
In the l0 years since the identification of HIV-l-specific cytotoxic T lymphocytes (CTL) in infected persons, this cellular immune response has been investigated in more depth than in any other human viral infection. Despite substantial advances in understanding many features of this arm of the host defense, fundamental issues regarding the role of CTL in protecting from disease progression remain undefined, and the failure of CTL to effectively compete with the virus over the course of infection is unexplained. Recent advances from numerous laboratories are now beginning to shed light on these issues, and form the basis for the generation of new hypotheses.