Catalysis of Phosphorus(V)-Mediated Transformations: Dichlorination Reactions of Epoxides Under Appel Conditions
Catalysis of Phosphorus(V)-Mediated Transformations: Dichlorination Reactions of Epoxides Under Appel Conditions
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DOI：
10.1021/ol102010h
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发表时间：
2010-10-15
期刊：
影响因子：
5.2
通讯作者：
Przeslak, Adam
中科院分区：
文献类型：
--
作者：
Denton, Ross M.;Tang, Xiaoping;Przeslak, Adam
研究了三苯基氧化膦催化的环氧化物1，2-二氯化反应。该反应对一系列末端和内部环氧化物是有效的。与经典的阿佩西尔型环氧化物二氯化反应不同，草酰氯被用作化学计量学试剂，由催化的三苯基氧化膦生成负责二氯化反应的氯膦盐。
A stereospecific triphenylphosphine oxide-catalyzed 1,2-dichlorination reaction of epoxides has been developed. The reaction is effective for a range of terminal and internal epoxides In contrast to the classical Appel-type dichlorination of epoxides, oxalyl chloride is used as a stoichrometric reagent to generate the chlorophosphonium salt responsible for dichlorination from catalytic triphenylphosphine oxide.