Biofilm Elimination on Intravascular Catheters: Important Considerations for the Infectious Disease Practitioner
Biofilm Elimination on Intravascular Catheters: Important Considerations for the Infectious Disease Practitioner
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DOI：
10.1093/cid/cir077
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发表时间：
2011-04-15
影响因子：
11.8
通讯作者：
Donlan, Rodney M.
中科院分区：
文献类型：
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作者：
Donlan, Rodney M.
血管内导管上生物膜的存在及其在导管相关血流感染中的作用是公认的。导管相关生物膜微生物对全身抗菌治疗的耐受性以及在医疗保健环境中产生抗菌药物耐药性的可能性强调了替代治疗策略的重要性。生物膜是微生物群落，具有独特的特征，在评估生物膜预防或控制策略的潜力时必须考虑这些特征。由于生物膜相关感染对许多抗微生物剂的治疗可达到的浓度不一致，因此对缓慢生长的生物膜细胞更有效的治疗或可以渗透生物膜基质的组合治疗可能更有效。也研究了不含抗菌药物的替代策略。这些方法有可能预防或消除留置血管内导管上的生物膜，并预防或解决导管相关感染。
The presence of biofilms on intravascular catheters and their role in catheter-related bloodstream infections is well accepted. The tolerance of catheter-associated biofilm organisms toward systemic antimicrobial treatments and the potential for development of antimicrobial resistance in the health care environment underscores the importance of alternative treatment strategies. Biofilms are microbial communities that exhibit unique characteristics that must be considered when evaluating the potential of biofilm prevention or control strategies. Because biofilm-associated infections do not respond consistently to therapeutically achievable concentrations of many antimicrobial agents, treatments that are more effective against slowly growing biofilm cells or combination treatments that can penetrate the biofilm matrix may be more effective. Alternative strategies that do not incorporate antimicrobial drugs have also been investigated. These approaches have the potential to prevent or eradicate biofilms on indwelling intravascular catheters and prevent or resolve catheter-related infections.