Functional and biocompatibility performances of an integrated Maglev pump-oxygenator.
Functional and biocompatibility performances of an integrated Maglev pump-oxygenator.
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集成磁悬浮泵氧合器的功能和生物相容性性能。
DOI：
10.1111/j.1525-1594.2008.00672.x
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发表时间：
2009
影响因子：
2.4
通讯作者：
Wu,ZhongjunJ
中科院分区：
文献类型：
--
作者：
Zhang,Tao;Cheng,Guangming;Koert,Andrew;Zhang,Juntao;Gellman,Barry;Yankey,GKwame;Satpute,Aditee;Dasse,KurtA;Gilbert,RichardJ;Griffith,BartleyP;Wu,ZhongjunJ
为了给肺衰竭患者提供呼吸支持，正在开发一种新型紧凑型集成泵氧合器。介绍了该器械的功能和生物相容性性能。泵式氧合器的设计是将磁悬浮泵/转子与独特配置的中空纤维膜束相结合，以创建一个免组装、超紧凑、一体化系统。在体外循环流动回路和绵羊动物模型中研究了这种新型装置的血液动力学、气体传输和生物相容性性能。体外结果表明，该器械能够在较宽的压力范围内泵送2至8 L/min的血流量，并在6 L/min的血流量下输送超过300 mL/min的氧转移速率。血液损伤试验表明，在100 mm Hg后负荷下，5 L/min的流速下溶血较低（标准化溶血指数[NIH] ≤ 0.04）。 5项动物实验（4 h至7天）的数据表明，该器械可使静脉血接近完全氧饱和状态（98.6% ± 1.3%）。 最高氧气传输速率达到386 mL/min。在3只7天动物的研究期间，气体传输性能稳定。 没有任何迹象表明血液受损。血浆游离血红蛋白和血小板计数在正常范围内。未发现泵组件和纤维表面有明显血栓。体外和体内结果均表明，新开发的泵式氧合器可实现充足的血流和氧输送，具有良好的生物相容性。
To provide respiratory support for patients with lung failure, a novel compact integrated pump‐oxygenator is being developed. The functional and biocompatibility performances of this device are presented. The pump‐oxygenator is designed by combining a magnetically levitated pump/rotor with a uniquely configured hollow fiber membrane bundle to create an assembly free, ultracompact, all‐in‐one system. The hemodynamics, gas transfer and biocompatibility performances of this novel device were investigated both in vitro in a circulatory flow loop and in vivo in an ovine animal model. The in vitro results showed that the device was able to pump blood flow from 2 to 8 L/min against a wide range of pressures and to deliver an oxygen transfer rate more than 300 mL/min at a blood flow of 6 L/min. Blood damage tests demonstrated low hemolysis (normalized index of hemolysis [NIH]∼0.04) at a flow rate of 5 L/min against a 100‐mm Hg afterload. The data from five animal experiments (4 h to 7 days) demonstrated that the device could bring the venous blood to near fully oxygen‐saturated condition (98.6% ± 1.3%). The highest oxygen transfer rate reached 386 mL/min. The gas transfer performance was stable over the study duration for three 7‐day animals. There was no indication of blood damage. The plasma free hemoglobin and platelet count were within the normal ranges. No gross thrombus is found on the explanted pump components and fiber surfaces. Both in vitro and in vivo results demonstrated that the newly developed pump‐oxygenator can achieve sufficient blood flow and oxygen transfer with excellent biocompatibility.