Peripheral adrenomedullin inhibits gastric emptying through CGRP8-37-sensitive receptors and prostaglandins pathways in rats
Peripheral adrenomedullin inhibits gastric emptying through CGRP8-37-sensitive receptors and prostaglandins pathways in rats
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DOI：
10.1016/j.peptides.2005.11.003
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发表时间：
2006-06-01
期刊：
影响因子：
3
通讯作者：
Tache, Y.
中科院分区：
文献类型：
--
作者：
Martinez, V.;Wang, L.;Tache, Y.
本文观察了静脉注射肾上腺髓质素（AM）对清醒大鼠胃排空的影响。AM在1.2nmol/kg剂量下对胃排空的抑制作用最大为50%。AM的效力比α-降钙素基因相关肽（α-CGRP）低约两倍，α-CGRP在0.6 nmol/kg时诱导类似的50%最大胃排空抑制。静脉注射AM和α-CGRP诱导的胃排空延迟可通过外周注射选择性CGRP（1）拮抗剂CGRP（8-37）和吲哚美辛预处理来预防，而用普萘洛尔阻断交感神经系统则不能改变。这些数据表明，外周AM通过与CGRP（8-37）-敏感受体（可能是CGRP（1）受体）相互作用以及募集阿司甘肽依赖性机制来抑制胃排空。(c)2005年爱思唯尔公司All rights reserved.
The effects of intravenous (iv) adrenomedullin (AM) on gastric emptying were investigated in conscious rats. AM induced a maximal 50% inhibition of gastric emptying at a dose of 1.2 nmol/kg. AM was about two-fold less potent than a-calcitonin gene-related peptide (alpha-CGRP), which induced a similar 50% maximal inhibition of gastric emptying at 0.6 nmol/kg. Delayed gastric emptying induced by i.v. AM and alpha-CGRP was prevented by peripheral injection of the selective CGRP(1) antagonist, CGRP(8-37), and by pretreatment with indomethacin, while not altered by blockade of the sympathetic nervous system with propranolol. These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP(8-37)-sensitive receptors, likely CGRP(1) receptors, and the recruitment of prostazglandin-dependent mechanisms. (c) 2005 Elsevier Inc. All rights reserved.