ACTIVITY OF SEROTONIN-CONTAINING NEURONS IN THE NUCLEUS RAPHE PALLIDUS OF FREELY MOVING CATS
ACTIVITY OF SEROTONIN-CONTAINING NEURONS IN THE NUCLEUS RAPHE PALLIDUS OF FREELY MOVING CATS
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DOI：
10.1016/0006-8993(82)90743-0
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
JACOBS, BL
中科院分区：
文献类型：
--
作者：
HEYM, J;STEINFELS, GF;JACOBS, BL
自由活动的猫的中缝苍白核（NRP）内的血清素能神经元最初以其缓慢（< 8 Hz）、有规律的放电和长持续时间（平均值 = 2.3 ms）的动作电位为特征。血清素能 NRP 神经元的活性在主动清醒期间最高（平均值 = 4.85 .+-. 0.37 脉冲/秒），并在从清醒到慢波睡眠 [SWS] 的过渡期间逐渐减慢，放电模式几乎没有变化（SWS 的中间：平均值 = 3.76 .+-. 0.36 脉冲/秒）。在快速眼动睡眠中，放电率急剧下降（平均值 = 0.92 .+-. 0.23 峰值/秒）并且放电规律性丧失。尽管主动和安静清醒时的放电率没有显着差异，但在 EMG [肌电图] 短暂升高期间放电率显着增加，但这些放电率增加通常仅与特定的运动行为相关。 SWS 期间血清素能 NRP 神经元的活动与皮质 EEG 中睡眠纺锤波的出现或从外侧膝状核记录的 PGO [脑桥膝枕波] 波的发生无关。这些神经元对阶段性听觉或视觉刺激也相对无反应，大多数被检查的神经元表现出较弱的兴奋反应。所测试的所有血清素能NRP神经元的活性均被血清素能激动剂5-甲氧基-N,N-二甲基色胺(250μg/kg，肌内注射)抑制(平均值＝-81.3±4.3％)。这项研究与之前关于中缝背核血清素能神经元的研究进行了比较，并讨论了中枢血清素能系统的同质性问题。
Serotonergic neurons within nucleus raphe pallidus (NRP) of freely moving cats initially were distinguished by their slow (< 8 Hz), regular discharge and long duration (mean = 2.3 ms) action potentials. The activity of serotonergic NRP neurons was highest during active waking (mean = 4.85 .+-. 0.37 spikes/s) and gradually slowed, with little change in firing pattern, during the transition from waking through slow wave sleep [SWS] (middle of SWS: mean = 3.76 .+-. 0.36 spikes/s). In REM sleep there was a precipitous decrease in firing rate (mean = 0.92 .+-. 0.23 spikes/s) and loss of discharge regularity. Although there was no significant difference in firing rate between active and quiet waking, discharge rates were significantly increased during transient elevations of the EMG [electromyogram], but these rate increases usually were associated with specific motor behaviors only. The activity of serotonergic NRP neurons during SWS was not related to the occurrence of either sleep spindles in the cortical EEG or PGO [ponto-geniculo-occipital wave] waves recorded from the lateral geniculate nucleus. These neurons also were relatively unresponsive to phasic auditory or visual stimuli, with most of the neurons examined showing weak excitatory responses. Activity of all serotonergic NRP neurons tested was suppressed (mean = -81.3 .+-. 4.3%) by the serotonergic agonist 5-methoxy-N,N-dimethyltryptamine (250 .mu.g/kg, i.m.). This study was compared with previous ones on serotonergic neurons in the dorsal raphe nucleus, and the issue of homogeneity in central serotonergic systems is discussed.