Three-Combination Probiotics Therapy in Children With Salmonella and Rotavirus Gastroenteritis
Three-Combination Probiotics Therapy in Children With Salmonella and Rotavirus Gastroenteritis
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DOI：
10.1097/mcg.0b013e31828f1c6e
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发表时间：
2014-01-01
影响因子：
2.9
通讯作者：
Chen, Kow-Tong
中科院分区：
文献类型：
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作者：
Huang, Yung-Feng;Liu, Po-Yen;Chen, Kow-Tong
目的：用定量Vesikari评分和定性严重腹泻(Vesikari评分11)评估沙门氏菌引起的和轮状病毒引起的胃肠炎的严重程度。严重腹泻的显著减少(Vesikari评分11)被用来评估三种组合益生菌(BIO-3)的疗效。背景：多项研究表明，轮状病毒和沙门氏菌感染是感染性胃肠炎的主要原因。虽然益生菌在一些研究中是有效的，但使用三联制剂益生菌的情况很少。研究：这项单中心、开放标签、随机、对照的试验包括159例感染性胃肠炎患者，年龄范围从2009年2月到2010年10月。结果：根据病原体进行分组(沙门氏菌48例，轮状病毒42例，来源不明69例)。服用Bio-3的儿童总腹泻持续时间明显缩短(P
Goals:Quantitative Vesikari scales and qualitative severe diarrhea (Vesikari scale 11) assessments were used to grade the Salmonella-induced and rotavirus-induced gastroenteritis severity. A significant reduction in severe diarrhea (Vesikari score 11) was used to evaluate the efficacy of three-combination probiotics (BIO-THREE).Background:Several studies have shown that rotavirus and Salmonella infections are the leading causes of infectious gastroenteritis. Although probiotics have been effective in some studies, the use of 3-combination formulation probiotics is rare.Study:This single-center, open-label, randomized, controlled trial included 159 patients (age range, 3 mo to 14 y) hospitalized with infectious gastroenteritis between February 2009 and October 2010.Results:Patients were grouped according to the pathogen identified (48, Salmonella; 42, rotavirus; and 69, unknown origin). The total diarrhea duration was significantly shorter for children who received BIO-THREE (P