Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera
Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera
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DOI：
10.1001/archopht.122.11.1642
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发表时间：
2004-11-01
影响因子：
--
通讯作者：
Reinke, J
中科院分区：
文献类型：
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作者：
Klein, R;Meuer, SM;Reinke, J
目的：比较数字和立体电影images.Design：仪器验证study.Participants：62名受试者（124只眼）与不同程度的AMD，包括没有AMD.Methods：视盘和黄斑的图像采用45度数码相机（630万像素）通过暗适应瞳孔和散瞳瞳孔。另外，通过对同一只眼睛的瞳孔放大，拍摄30 °立体视网膜胶片图像。采用改良的威斯康星州视网膜相关黄斑病变分级系统，对所有图像进行玻璃疣大小、类型和面积、色素异常、地图样萎缩和新生血管病变分级。精确的协议和未加权的kappa得分计算配对分级导致从数字和电影images.Main结果Measure：从立体幻灯片colorimages和数字nonstereoscopic images.Results之间的协议获得的分级之间的数字和立体电影图像，通过散瞳分级之间的精确协议为91%（kappa=0.85）的类别没有，早期AMD，和晚期AMD。通过暗适应的瞳孔拍摄的数字图像的分级与电影图像的分级相比，准确的协议是80%（Kappa=0.69）。通过暗适应和散瞳的数字图像捕获的分级的精确一致性为86%（kappa=0.78）。此外，Kappa评分为不同的方法之间的协议为个别insulines.Conclusions：从高分辨率的数字图像，特别是当瞳孔被放大，导致的分级是中等，几乎perfect.Conclusions的，是可比的，从电影为基础的图像。我们的结论是，数字成像的视网膜是有用的流行病学研究AMD。
Objective: To compare gradings of lesions associated with age-related macular degeneration (AMD) from digital and stereoscopic film images.Design: Instrument validation study.Participants: Sixty-two subjects (124 eyes) with varying degrees of AMD, including no AMD.Methods: images of the optic disc and macula were taken using a 45degrees digital camera (6.3 megapixels) through dark-adapted pupils and pharmacologically dilated pupils. In addition, 30degrees stereoscopic retinal film images were taken through pharmacologically dilated pupils of the same eyes. All images were graded for drusen size, type, and area; pigmentary abnormalities; geographic atrophy; and neovascular lesions using the modified Wisconsin Age-Related Maculopathy Grading System. Exact agreement and unweighted kappa scores were calculated for paired gradings resulting from digital and film images.Main Outcome Measure: Agreement between gradings obtained from stereoscopic slide transparencies and digital nonstereoscopic images.Results: Exact agreement between gradings of digital and stereoscopic film images taken through pharmacologically dilated pupils was 91% (kappa=0.85) for the categories of none, early AMD, and late AMD. Exact agreement for gradings of digital images taken through dark-adapted pupils compared with gradings of film images was 80% (kappa=0.69). Exact agreement for gradings of digital images captured through dark-adapted and pharmacologically dilated pupils was 86% (kappa=0.78). In addition, kappa scores for agreement between different approaches for individual lesions were moderate to almost perfect.Conclusions: Gradings resulting from high-resolution digital images, especially when the pupil is pharmacologically dilated, are comparable with those resulting from film-based images. We conclude that digital imaging of the retina is useful for epidemiological studies of AMD.