Diet, smoking and lung cancer: a case-control study of 1000 cases and 1500 controls in South-West England.
Diet, smoking and lung cancer: a case-control study of 1000 cases and 1500 controls in South-West England.
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饮食，吸烟和肺癌：一项对西南英格兰1000例和1500例对照的病例对照研究。
DOI：
10.1054/bjoc.2000.1668
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发表时间：
2001-03-02
影响因子：
8.8
通讯作者：
Silcocks, P
中科院分区：
文献类型：
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作者：
Darby, S;Whitley, E;Doll, R;Key, T;Silcocks, P
我们在一项病例对照研究中研究了饮食与肺癌的关系，该研究涉及英格兰西南部的982例肺癌患者和1486名对照人群。在这项研究中，受试者接受了个人访谈，询问他们的吸烟习惯，以及他们对富含视黄醇或胡萝卜素的食物和补充剂的摄入量。对15个饮食变量进行了分析，包括预先形成的视黄醇和胡萝卜素的摄入量。在13个变量中，有13个变量与肺癌风险显著相关(P<；0.01)，其中8个变量在扣除吸烟因素后仍然存在。当同时考虑15个变量时，5个独立的显著相关性仍然存在：预先形成的视黄醇(风险增加)，以及鱼肝油、维生素丸、胡萝卜和番茄酱(风险降低)。这五种关联都不太可能代表生物效应，或者它们都可以通过吸烟或偏见的残留混淆来解释。我们的结论是，在这一人群中，至少有一个尚未确定的因素与肺癌风险有因果关系，并且在归因风险方面具有相当重要的意义。©2001癌症研究活动http://www.bjcancer.com
We have examined the relationship between diet and lung cancer in a case–control study of 982 cases of lung cancer and 1486 population controls in south-west England in which subjects were interviewed personally about their smoking habits and their consumption of foods and supplements rich in retinol or carotene. Analyses were performed for 15 dietary variables, including intake of pre-formed retinol and carotene. There were significant associations (P< 0.01) with lung cancer risk for 13 of the variables, eight of which remained after adjustment for smoking. When the 15 variables were considered simultaneously, independent significant associations remained for 5: pre-formed retinol (increased risk), and fish liver oil, vitamin pills, carrots and tomato sauce (decreased risk). It is unlikely that all five associations represent biological effects, or that they can all be explained by residual confounding by smoking, or by biases. We conclude that there is at least one as yet unidentified factor that is causally related to lung cancer risk and of considerable importance in terms of attributable risk in this population. © 2001 Cancer Research Campaign http://www.bjcancer.com