No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia
No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia
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DOI：
10.1016/s0304-3940(98)00781-2
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发表时间：
1998-11-13
影响因子：
2.5
通讯作者：
Sasaki, H
中科院分区：
文献类型：
--
作者：
Arai, H;Satoh-Nakagawa, T;Sasaki, H
Tau protein levels in cerebrospinal fluid (CSF-tau) were determined in 29 patients with old cerebrovascular disease (CVD, 21 demented and eight non-demented), 69 patients with Alzheimer's disease (AD) and 17 age-matched normal controls. The CSF tau level in the vascular dementia (VD) group (24.0 +/- 17.0 pg/ml) was significantly lower (P < 0.0001) than that in the AD group (90.0 +/- 45.3 pg/ml), but not significantly different from that in the non-demented patients with CVD (18.1 +/- 10.2 pg/ml) or controls (20.3 +/- 13.0 pg/ml). Among the VD patients, 1/21 exceeded a cut-off value (mean +/- 2 SD of controls), whereas 8/69 of the AD patients had CSF-tau levels below this value. These findings suggest that VD constitutes a group of dementias that can be separated from AD by normal CSF-tau levels. CSF-tau determinations in combination with other clinical findings may provide another diagnostic aid in the differential diagnosis between VD and AD. (C) 1998 Elsevier Science ireland Ltd. All rights reserved.
