The effect of ozone on inner-city children with asthma - Identification of susceptible subgroups
The effect of ozone on inner-city children with asthma - Identification of susceptible subgroups
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DOI：
10.1164/ajrccm.162.5.9908113
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发表时间：
2000-11-01
影响因子：
24.7
通讯作者：
Redline, S
中科院分区：
文献类型：
--
作者：
Mortimer, KM;Tager, IB;Redline, S
在846名4至9岁的市中心哮喘儿童的队列中，我们寻找更容易受到夏季臭氧影响的亚组。每日日记与环境臭氧水平进行比较，以评估人口和环境特征的影响修改。早产> 3周或体重< 5.5磅的儿童。与正常出生体重的足月儿相比，在早晨%最大呼气流速（PEFR）下降更大（1.8%对0.3%/15 ppb臭氧，p < 0.05），早晨症状发生率更高（比值比= 1.42对1.09/15 ppb臭氧，p < 0.05）。在低出生体重（LBW）或早产儿的儿童中，与β受体激动剂或黄嘌呤类药物（0.8%）或克罗埃西亚无类固醇（0.1%）相比，报告基线药物类别为“无药物”（3.2%下降）或“类固醇”（2.7%）的儿童下降幅度更大。在出生体重正常的儿童和足月婴儿中，crologyn无类固醇组的%PEFR下降最大（1.3%，其他三组均< 0.5%）。非过敏性儿童对臭氧也有更大的反应。我们得出结论，在哮喘队列中，LBW或早产的儿童对臭氧的反应最大。
Within a cohort of 846 inner-city asthmatic children aged 4 to 9 yr, we looked for subgroups that were more susceptible to the effects of summer ozone. Daily diaries were compared with ambient ozone levels to evaluate effect modification by demographic and environmental characteristics. Children born > 3 wk prematurely or weighing < 5.5 Ib. had greater declines in morning % peak expiratory flow rate (PEFR) (1.8% versus 0.3% per 15 ppb ozone, p < 0.05) and a higher incidence of morning symptoms (odds ratio = 1.42 versus 1.09 per 15 ppb ozone, p < 0.05) than did children who had been full-term infants of normal birthweight. Among children who had been of low birthweight (LBW) or had been premature infants, greater declines were seen among those whose reported baseline medication category was "no medication" (3.2% decline) or "steroids" (2.7%) as opposed to beta agonists or xanthines (0.8%) or cromolyn without steroids (0.1%). Among the children who had been normal birthweight and full-term infants, the cromolyn without steroids group had the greatest declines in %PEFR (1.3%, versus < 0.5% in each of the other three groups). Nonatopic children also had greater responses to ozone. We conclude that among an asthmatic cohort, children who had had an LBW or a premature birth showed the greatest responses to ozone.