Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.
Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.
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DOI：
10.1016/j.heares.2012.01.009
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发表时间：
2012-06
期刊：
影响因子：
2.8
通讯作者：
Raible DW
中科院分区：
文献类型：
--
作者：
Ou H;Simon JA;Rubel EW;Raible DW
斑马鱼侧线是一种有效的模型系统，用于评估保护和损伤毛细胞的化学物质。侧线毛细胞位于身体表面，便于操作和可视化。斑马鱼侧线系统可以快速筛选大型化学库，以及随后对感兴趣的化合物进行全面评估。在这篇综述中，我们专注于我们以前的屏幕和我们的屏幕保护毛细胞的化学品，和使用斑马鱼侧线损害毛细胞的化学品的不断发展的方法的结果。
The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body, lateral line hair cells are accessible for manipulation and visualization. The zebrafish lateral line system allows rapid screens of large chemical libraries, as well as subsequent thorough evaluation of interesting compounds. In this review, we focus on the results of our previous screens and the evolving methodology of our screens for chemicals that protect hair cells, and chemicals that damage hair cells using the zebrafish lateral line.