Antidepressant-like effects of melatonin in the mouse chronic mild stress model
Antidepressant-like effects of melatonin in the mouse chronic mild stress model
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DOI：
10.1016/j.ejphar.2009.02.037
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发表时间：
2009-04-01
影响因子：
5
通讯作者：
Elisabetsky, Elaine
中科院分区：
文献类型：
--
作者：
Detanico, Bernardo C.;Piato, Angelo L.;Elisabetsky, Elaine
褪黑激素是一种主要由松果体合成的激素，已被证明可以控制季节和昼夜节律，以及免疫系统，某些行为和对压力的反应。慢性应激与人类抑郁症的病因有关，抑郁症患者存在昼夜节律和季节节律的变化。本研究调查了每日外源性褪黑激素（1和10 mg/kg，p.o.）和丙咪嗪（20 mg/kg，i. p.）对小鼠不可预测的慢性轻度抑郁应激模型引起的被毛状态、梳理行为和皮质酮水平的变化的影响。正如预期的那样，5周的不可预测的慢性轻度应激时间表诱导了被毛状态的显著退化，梳理减少和血清皮质酮水平升高。所有这些不可预测的慢性轻度应激引起的变化都被褪黑素抵消（P
Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress. Chronic exposure to stress is involved in the etiology of human depression, and depressed patients present changes in circadian and seasonal rhythms. This study investigated the effects of daily exogenous melatonin (1 and 10 mg/kg, p.o.) and imipramine (20 mg/kg, i.p.) on the changes in the coat state, grooming behaviour and corticosterone levels induced by the unpredictable chronic mild stress model of depression in mice. As expected, the 5 weeks of unpredictable chronic mild stress schedule induced significant degradation of the coat state, decreased grooming and increased serum corticosterone levels. All of these unpredictable chronic mild stress-induced changes were counteracted by melatonin (P