INFLUENCE OF CEREBRAL ACTIVITY IN WAKEFULNESS ON REGULATION OF BREATHING
INFLUENCE OF CEREBRAL ACTIVITY IN WAKEFULNESS ON REGULATION OF BREATHING
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DOI：
10.1152/jappl.1961.16.1.15
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发表时间：
1961-01-01
影响因子：
3.3
通讯作者：
FINK, BR
中科院分区：
文献类型：
--
作者：
FINK, BR
13名健康男性，不知道本研究的客观性，进行被动或主动过度通气降低呼气末二氧化碳张力至25毫米汞柱或以下。在过度换气期结束时，节律性呼吸以大约控制频率持续不间断。在恢复的第一分钟，通气量高于控制量，然后稳定在控制量的约三分之二;在此水平持续超过10分钟，在此期间，呼气末PCO 2逐渐上升到控制水平。未发生周期性呼吸。在清醒状态下没有过度呼吸暂停，而在全身麻醉时容易诱发。它的结论是，与清醒相关的大脑活动是正常的呼吸驱动的一个组成部分，和二氧化碳的行为，通过增强这一组成部分的影响。
Thirteen healthy men, unaware of the objectivies of this study, underwent passive or active overventilation lowering the end-expiration carbon dioxide tension to 25 mm. Hg or below. At the end of the period of hyperventilation, rhythmic respiration continued uninterrupted at approximately the control frequency. The volume of ventilation was above control during the first minute of recovery and then stabilized at about two-thirds of the control volume; it continued at this level for over 10 minutes during which time the end-expiration PCO2 gradually rose toward the control level. No instance of periodic breathing occurred. The absence of overventilatory apnea in the waking condition contrasts with its easy elicitation during general anesthesia. It is concluded that cerebral activity associated with wakefulness is a component of the normal respiratory drive, and that carbon dioxide acts by augmenting the effects of this component.