SENSITIZATION TO CHORTOGLYPHUS-ARCUATUS AND ALEUROGLYPHUS-OVATUS IN DERMATOPHAGOIDES SPP ALLERGIC INDIVIDUALS
SENSITIZATION TO CHORTOGLYPHUS-ARCUATUS AND ALEUROGLYPHUS-OVATUS IN DERMATOPHAGOIDES SPP ALLERGIC INDIVIDUALS
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DOI：
10.1111/j.1365-2222.1993.tb00306.x
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发表时间：
1993-02-01
影响因子：
6.1
通讯作者：
CARABALLO, LR
中科院分区：
文献类型：
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作者：
PUERTA, L;FERNANDEZCALDAS, E;CARABALLO, LR
本文对77例变应性哮喘和（或）慢性变应性鼻炎患者进行了卵形粉螨（Ao）和角螨（Ca）特异性IgE的检测。所有这些个体对屋尘螨（Dp）和/或粉尘螨（Df）提取物的皮肤试验（weal大于或等于3 mm）均呈阳性。来自29个非特应性个体的血清用作对照。当血清结合率大于或等于添加的总计数的1%时，认为RAST为阳性。对Dp的RAST阳性率为75.3%，对两种储藏螨（Ao和Ca）中的至少一种的RAST阳性率为76.6%。在Dp阳性的RAST患者中，Ao和Ca阳性率分别为79.3%和75.8%。RAST抑制研究与高RAST结合所有三个螨13名受试者的血清池显示Ao和Ca之间的显着交叉反应性和DP和Ao和Ca之间的最低至中度交叉反应性。这项研究表明，在哥伦比亚卡塔赫纳的呼吸道过敏患者中，对Ao和Ca的致敏作用很常见，并表明Ao、Ca和Dp具有独特和共同的过敏原决定因素。
The prevalence of specific IgE to the storage mites Aleuroglyphus ovatus (Ao) and Chortoglyphus arcuatus (Ca) was studied in 77 individuals with allergic asthma and/or chronic allergic rhinitis. All these individuals had a positive skin test (weal greater-than-or-equal-to 3 mm) to extracts of Dermatophagoides pteronyssinus (Dp) and/or Dermatophagoides farinae (Df). Sera from 29 non-atopic individuals were used as controls. A RAST was considered positive when a serum bound greater-than-or-equal-to 1% of the total counts added. The prevalence of a positive RAST to Dp was 75.3%, and to at least one of the two storage mites (Ao and Ca), 76.6%. Among patients with a positive RAST to Dp, 79.3% and 75.8% were RAST positive to Ao and Ca, respectively. RAST inhibition studies with a pool of sera from 13 subjects with high RAST binding to all three mites showed significant crossreactivity between Ao and Ca and minimal to moderate crossreactivity between Dp and Ao and Ca. This study demonstrates that sensitization to Ao and Ca is common in individuals with respiratory allergies in Cartagena, Colombia and suggests that Ao, Ca and Dp have unique and common allergenic determinants.