Transcriptomics Inform Hierarchical Neuroimaging Features Relevant for Psychosis Spectrum Symptoms.
Transcriptomics Inform Hierarchical Neuroimaging Features Relevant for Psychosis Spectrum Symptoms.
复制标题
转录组学为与精神病谱系症状相关的分层神经影像学特征提供信息。
DOI：
10.1016/j.biopsych.2020.05.016
复制
发表时间：
2020
影响因子：
10.6
通讯作者：
Anticevic,Alan
中科院分区：
文献类型：
--
作者：
Ji,JieLisa;Burt,JoshuaB;Anticevic,Alan
对 Rafael Romero-Garcia 等人的文章的评论（参见记录 2020-08234-001）。罗梅罗-加西亚等人。量化区域皮质 MT 与个体受试者的精神分裂行为程度以及艾伦人脑图谱基因的皮质表达之间的关系。尽管本研究中患有精神分裂症的个体不符合精神分裂症（SZ）或其他精神病谱系障碍的诊断标准，但他们表现出减轻的精神病谱系障碍相关症状。作者推测，精神分裂症的行为特征可能与结构神经特征的区域变化有关，例如他们使用 MT 测量的髓鞘形成，以及与 SZ 相关的皮质基因失调。 Romero-Garcia 等人使用的新颖方法。强调了比较转录组和神经数据的另一个关键困难。本文的另一个关键方面与其交叉诊断的影响有关。先前的研究报道，与疾病相关的基因集，包括精神分裂症、双相情感障碍、自闭症谱系障碍和重度抑郁症，具有很强的层次梯度的基因显着富集。通过结合几种互补的方法和数据集，Romero-Garcia 等人。演示了如何使用转录组数据来了解疾病相关行为的机制。（PsycInfo 数据库记录 (c) 2020 APA，保留所有权利）
Comments on an article by Rafael Romero-Garcia et al.(see record 2020-08234-001). Romero-Garcia et al. quantify the relationship between regional cortical MT and both the degree of schizotypal behavior in individual subjects and the cortical expression of genes from the Allen Human Brain Atlas. Though the individuals with schizotypy in this study do not meet the diagnostic criteria for schizophrenia (SZ) or other psychosis spectrum disorders, they display attenuated psychosis spectrum disorder–relevant symptoms. The authors hypothesize that the behavioral traits of schizotypy may be linked with regional changes in structural neural features such as myelination, which they measure using MT, as well as SZ-related dysregulation of genes in the cortex. The novel methodology used by Romero-Garcia et al. highlights another key difficulty with comparing transcriptomic and neural data. Another key aspect of this article relates to its crossdiagnostic implications. Previous work has reported that disease-related gene sets, including for SZ, bipolar disorder, autism spectrum disorder, and major depressive disorder, are significantly enriched for genes with a strong hierarchical gradient. By combining several complementary methodologies and datasets, Romero-Garcia et al. demonstrated how transcriptomic data can be used to inform the mechanisms underlying disease-relevant behavior.(PsycInfo Database Record (c) 2020 APA, all rights reserved)