MTA family of transcriptional metaregulators in mammary gland morphogenesis and breast cancer
MTA family of transcriptional metaregulators in mammary gland morphogenesis and breast cancer
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DOI：
10.1007/s10911-007-9043-7
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发表时间：
2007-09-01
影响因子：
2.5
通讯作者：
Kumar, Rakesh
中科院分区：
文献类型：
--
作者：
Singh, Rajesh R.;Kumar, Rakesh
由于乳腺癌及其相关的转移是一个全球性的健康问题和妇女死亡的主要原因，研究工作，以了解乳腺的发育，形态发生和功能是一个高度优先事项。在乳腺的正常功能和肿瘤转化中已经鉴定出无数的信号通路、转录因子和相关的转录辅调节因子。转移肿瘤抗原1（MTA1）基因的发现、其在癌症和转移中的过表达及其随后作为染色质重塑复合物的组成部分的鉴定预示着对其生理作用的广泛研究。随后对其他基因家族成员，即MTA1、MTA2和MTA3及其在细胞中的功能的鉴定导致了NITA家族重要性的确立。这些蛋白质在调节正常乳腺和乳腺癌中的激素反应中的作用已经导致它们被鉴定为重要的分子标记物和潜在的治疗靶点。
Since breast cancer and its associated metastasis are a global health problem and a major cause of mortality among women, research efforts to understand the development, morphogenesis, and functioning of the mammary gland are a high priority. Myriad signaling pathways, transcription factors, and associated transcriptional coregulators have been identified in both normal functioning and neoplastic transformation of the mammary gland. The discovery of the metastasis tumor antigen 1 (MTA1) gene, its overexpression in cancer and metastasis and its subsequent identification as an integral part of the chromatin remodeling complex heralded extensive research on its physiological role. Subsequent identification of additional gene family members, namely MTA1s, MTA2, and MTA3, and their functions in the cell has resulted in the establishment of the significance of the NITA family. The role of these proteins in modulating hormonal responses in normal mammary glands and in breast cancer has resulted in their identification as important molecular markers and potential therapeutic targets.