Changes in Adipokine Levels in Autism Spectrum Disorders
Changes in Adipokine Levels in Autism Spectrum Disorders
复制标题
自闭症谱系障碍中脂肪因子水平的变化
作者：
D. H. Rodrigues;N. Rocha;L. Sousa;I. Barbosa;A. Kummer;A. Teixeira
背景和目的：自闭症谱系障碍（ASD）的发病机制在很大程度上是未知的，但它似乎涉及在几个生物系统的功能障碍。在许多可能的生物学途径中，免疫系统已经成为潜在的参与者。最近的研究表明，细胞因子（介导免疫细胞相互作用的分子）和ASD之间的关联。脂肪因子是主要由脂肪组织分泌的细胞因子，可能具有全身性作用。本研究的主要目的是比较ASD患者和健康对照者的三种脂肪因子的血浆水平。另一个目的是将这些脂肪因子的水平与社会反应量表（SRS）测量的自闭症症状的严重程度相关联。研究方法：我们收集了30名患者和19名对照者的血浆，并使用市售试剂盒测量了脂联素、瘦素和β-内酰胺酶的水平。我们还使用SRS作为评估自闭症症状严重程度的工具。结果如下：我们发现，与对照组相比，ASD患者血浆中的Leptin水平降低，瘦素水平升高，脂联素水平不变。脂联素水平与SRS评估的症状严重程度之间也呈负相关。结论：ASD患者血浆脂肪因子水平有明显变化。它们表明ASD发生全身性变化，可能是该疾病的标志。
Background and Objective: The etiopathogenesis of autism spectrum disorders (ASD) is largely unknown, but it seems to involve dysfunction in several biological systems. Among many possible biological pathways, the immune system has emerged as potentially involved. Recent studies have shown association between cytokines (molecules that mediate immune cell interaction) and ASD. Adipokines are cytokines secreted mainly by adipose tissue and may have systemic effects. The main objective of this study was to compare the plasma levels of three adipokines between patients with ASD and healthy controls. Another aim was to correlate the levels of these adipokines and the severity of autistic symptoms as measured by the Social Responsiveness Scale (SRS). Methods: We collected plasma from 30 patients and 19 controls and measured the levels of adiponectin, leptin and resistin using a commercially available kit. We also used the SRS as a tool to assess the severity of autistic symptoms. Results: We found decreased levels of resistin, increased levels of leptin and unaltered levels of adiponectin in plasma from ASD subjects in comparison with controls. There was also a negative correlation between the levels of adiponectin and the severity of symptoms as assessed by the SRS. Conclusion: There are significant changes in the plasma levels of adipokines from patients with ASDs. They suggest the occurrence of systemic changes in ASD and may be hallmarks of the disease.