Aluminum-containing antacids as a cause of idiopathic Parkinson's disease
Aluminum-containing antacids as a cause of idiopathic Parkinson's disease
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DOI：
10.1054/mehy.1997.0701
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发表时间：
1999-07-01
影响因子：
4.7
通讯作者：
Altschuler, E
中科院分区：
文献类型：
--
作者：
Altschuler, E
特发性帕金森病（PD）的发病机制尚不清楚。在一项对200名PD患者和200名年龄和性别匹配的对照组进行的研究中，斯特朗指出，与对照组相比，PD患者的溃疡（通过X线或手术诊断）发生率明显且具有统计学意义（14%至4%）。这些结果已经讨论过，但从未解释过。研究表明，与对照组相比，PD患者黑质中的铝浓度增加。铝被认为是一种细胞毒素。在这里，我认为铝，特别是含铝抗酸剂可能有助于特发性PD的发病机制。
The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). These results have been discussed but never explained. Studies have shown increased concentrations of aluminum in the substantia nigra of PD patients compared to controls. Aluminum is thought to be a cellular toxin. Here I suggest that aluminum, and in particular aluminum-containing antacids may contribute to the pathogenesis of idiopathic PD.