A comparison of X-irradiation and ferrous ion-ascorbate on oxidation of phosphatidylglycerols in multilamellar liposomes.
A comparison of X-irradiation and ferrous ion-ascorbate on oxidation of phosphatidylglycerols in multilamellar liposomes.
复制标题
X 射线照射和亚铁离子抗坏血酸对多层脂质体中磷脂酰甘油氧化的比较。
DOI：
10.1007/bf01211363
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发表时间：
1987
影响因子：
1.7
通讯作者：
Yatvin,MB
中科院分区：
文献类型：
--
作者：
Ianzini,F;Yatvin,MB
本文报道了亚铁离子-抗坏血酸和X射线对由完全饱和、不饱和或饱和和不饱和脂肪酸混合物组成的多层脂质体的影响。脂质成分被证明在决定过氧化发生的程度上是至关重要的。由饱和和不饱和脂肪酸混合物组成的脂质体被抗坏血酸亚铁离子氧化的程度较小。这种减少的过氧化作用显然是饱和脂肪成分所表现出的抑制机制的结果。相反，由混合脂类组成的脂质体不能降低电离辐射引起的过氧化水平。这些结果表明，当使用化学氧化剂时，脂质体的组成在决定过氧化程度方面起作用，而当电离辐射为氧化剂时，组成是可以忽略不计的因素。
The effect of ferrous ion-ascorbate and X-radiation on multilamellar liposomes, composed of either completely saturated, unsaturated or a mixture of saturated and unsaturated fatty acids, is reported. Lipid composition is shown to be of critical importance in determining the extent to which peroxidation occurs. Liposomes composed of the mixture of saturated and unsaturated fatty acids are peroxidized to a lesser extent by ferrous ion-ascorbate. The reduced peroxidation is apparently the result of an inhibition mechanism shown by the saturated lipid component. In contrast, liposomes composed of mixed lipids do not reduce the level of peroxidation induced by ionizing radiation.These results show that the composition of liposomes plays a role in determining the extent to which peroxidation occurs when a chemical oxidant is employed, but composition is a negligible factor when ionizing radiation is the oxidant.