Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.
Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.
复制标题
用于构建和利用 AlloRep 数据库的出版物、结构分析和查询的数据。
DOI：
10.1016/j.dib.2016.07.006
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发表时间：
2016
期刊：
影响因子：
1.2
通讯作者：
Swint-Kruse,Liskin
中科院分区：
文献类型：
--
作者：
Sousa,FilipaL;Parente,DanielJ;Hessman,JacobA;Chazelle,Allen;Teichmann,SarahA;Swint-Kruse,Liskin
AlloRep 数据库 (www.AlloRep.org) (Sousa et al., 2016) [1] 编译了转录调节子 LacI/GalR 家族的广泛序列、诱变和结构信息。提供了 45 个旁系同源亚家族中超过 3000 个蛋白质的序列比对，并作为整个家族的子采样比对。通过对文献的详尽检索，汇编了近 6000 个突变体的表型和生化数据；本文包含对这些数据的引用。这些数据包括有关寡聚状态、稳定性、DNA 结合和变构调节的信息。 65 种蛋白质的蛋白质结构数据以易于访问的残基接触网络的形式呈现。最后，本文包含启用 AlloRep 数据库使用的示例查询。请参阅相关文章“AlloRep：LacI/GalR 转录调节因子的序列、结构和诱变数据存储库”（Sousa 等人，2016 年）[1]。
The AlloRep database (www.AlloRep.org) (Sousa et al., 2016) [1] compiles extensive sequence, mutagenesis, and structural information for the LacI/GalR family of transcription regulators. Sequence alignments are presented for >3000 proteins in 45 paralog subfamilies and as a subsampled alignment of the whole family. Phenotypic and biochemical data on almost 6000 mutants have been compiled from an exhaustive search of the literature; citations for these data are included herein. These data include information about oligomerization state, stability, DNA binding and allosteric regulation. Protein structural data for 65 proteins are presented as easily-accessible, residue-contact networks. Finally, this article includes example queries to enable the use of the AlloRep database. See the related article, “AlloRep: a repository of sequence, structural and mutagenesis data for the LacI/GalR transcription regulators” (Sousa et al., 2016) [1].