Insights into mammalian TE diversity through the curation of 248 genome assemblies
Insights into mammalian TE diversity through the curation of 248 genome assemblies
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DOI：
10.1126/science.abn1430
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发表时间：
2023-04-28
期刊：
影响因子：
56.9
通讯作者：
Ray, David A.
中科院分区：
文献类型：
--
作者：
Osmanski, Austin B.;Paulat, Nicole S.;Ray, David A.
我们检测了248个胎盘哺乳动物基因组组件的转座元件(TE)含量，这是迄今为止真核生物中最大的创新努力。我们发现，尽管哺乳动物在总TE含量和多样性上彼此相似，但它们在最近TE的积累方面显示出实质性的差异。这包括最近在哺乳动物树上发生的多次扩张和静止事件。年轻的TES，特别是长的穿插元件，推动基因组大小的增加，而DNA转座子与较小的基因组有关。哺乳动物往往在任何给定的时间只积累几种类型的TE，其中一种类型的TE占主导地位。我们还发现饮食习惯和DNA转座子入侵的存在之间存在关联。这些详细的注释将作为未来胎盘哺乳动物之间的比较TE分析的基准。
We examined transposable element (TE) content of 248 placental mammal genome assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that although mammals resemble one another in total TE content and diversity, they show substantial differences with regard to recent TE accumulation. This includes multiple recent expansion and quiescence events across the mammalian tree. Young TEs, particularly long interspersed elements, drive increases in genome size, whereas DNA transposons are associated with smaller genomes. Mammals tend to accumulate only a few types of TEs at any given time, with one TE type dominating. We also found association between dietary habit and the presence of DNA transposon invasions. These detailed annotations will serve as a benchmark for future comparative TE analyses among placental mammals.