Mediators of the socioeconomic gradient in outcomes of adult asthma and rhinitis.
Mediators of the socioeconomic gradient in outcomes of adult asthma and rhinitis.
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DOI：
10.2105/ajph.2012.300938
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发表时间：
2013-02
影响因子：
12.7
通讯作者：
Blanc PD
中科院分区：
文献类型：
--
作者：
Trupin L;Katz PP;Balmes JR;Chen H;Yelin EH;Omachi T;Blanc PD
我们估计了家庭和邻里环境因素在多大程度上可以解释成人哮喘和鼻炎结局的社会经济地位（SES）梯度。使用515例哮喘或鼻炎或两者兼有的成人的调查数据，我们使用哮喘严重程度量表和健康相关生活质量（HRQL）量表，研究了SES与疾病严重程度的环境介质。我们根据教育和家庭收入来定义社会经济地位。潜在的环境介质包括家庭类型和所有权，暴露于过敏原和刺激物，并认为邻里问题的总结措施。我们将每个结果建模为SES的函数，并控制年龄，性别和潜在的中介。SES中疾病严重程度和HRQL的变化明显。居住在租来的房子部分介导了严重程度和HRQL的SES梯度（P <0.01）。较高的邻里问题感知水平与较差的HRQL相关，并部分介导了收入-HRQL关系（P <0.01）。家庭和邻里环境的差异部分解释了SES与成人哮喘和鼻炎结局的相关性。
We estimated the extent to which socioeconomic status (SES) gradients in adult asthma and rhinitis outcomes can be explained by home and neighborhood environmental factors. Using survey data for 515 adults with either asthma or rhinitis, or both, we examined environmental mediators of SES associations with disease severity, using the Severity of Asthma Scale, and health-related quality of life (HRQL), using the Rhinasthma Scale. We defined SES on the basis of education and household income. Potential environmental mediators included home type and ownership, exposures to allergens and irritants, and a summary measure of perceived neighborhood problems. We modeled each outcome as a function of SES, and controlled for age, gender, and potential mediators. Gradients in SES were apparent in disease severity and HRQL. Living in a rented house partially mediated the SES gradient for both severity and HRQL (P < .01). Higher perceived levels of neighborhood problems were associated with poorer HRQL and partially mediated the income–HRQL relationship (P < .01). Differences in home and neighborhood environments partially explained associations of SES with adult asthma and rhinitis outcomes.