Peptide‐Modulated pH Rhythms
Peptide‐Modulated pH Rhythms
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肽调节 pH 节律
DOI：
10.1002/cphc.202200103
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发表时间：
2022
期刊：
影响因子：
2.9
通讯作者：
Epstein, Irving R.
中科院分区：
文献类型：
--
作者：
Liu, Mengfei;Yuan, Ling;Zhu, Chenghao;Pan, Changwei;Gao, Qingyu;Wang, Hongzhang;Cheng, Zhenfang;Epstein, Irving R.
许多药物调节和/或控制周期性过程的时空动态，如心跳、神经元信号和代谢，通常通过与蛋白质或寡肽相互作用。在这里，我们使用准生物相容性，非平衡pH振荡系统作为仿生生物钟来研究pH响应肽对节律动力学的影响。添加的多肽产生反馈，可以延长或缩短振荡周期，在此期间，多肽在随机线圈和螺旋线圈构象之间交替。这种对化学时钟的调节支持了短肽试剂可能作为调节人体时钟的药物的概念。
Many drugs adjust and/or control the spatiotemporal dynamics of periodic processes such as heartbeat, neuronal signaling and metabolism, often by interacting with proteins or oligopeptides. Here we use a quasi‐biocompatible, non‐equilibrium pH oscillatory system as a biomimetic biological clock to study the effect of pH‐responsive peptides on rhythm dynamics. The added peptides generate feedback that can lengthen or shorten the oscillatory period during which the peptides alternate between random coil and coiled‐coil conformations. This modulation of a chemical clock supports the notion that short peptide reagents may have utility as drugs to regulate human body clocks.